Analytical Support

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With strong scientific knowledge and experience in the regulatory requirements of both the international and domestic industry market, analytical development group of BOC Sciences has evolved to interleave with drug discovery, pharmaceutical development and manufacturing. State-of-the-art technologies and instrumentation along with close collaboration with synthetic organic chemists ensures the highest quality project execution that the right questions are asked and the right tools are used to solve even the most difficult problems. Typically, these can range from identifying an impurity in a manufacturing process, degradation products formed on storage or characterisation of a reference standard – all the way to a full Physical & Chemical Characterisation Study for a range of salt forms or polymorphs. BOC Sciences’ analytical development group supports projects in an integrated services motif, and ensures that the most progress is made in a timely and cost-effective manner.

-> Purity testing of starting materials and raw materials
-> Structural identification of impurities and degradation products
-> Structural elucidation and chemical characterisation of the intermediates and final compound
-> Physical & Chemical Characterisation Study of the compounds provided by customers
BOC Sciences offers a variety of analytical services, such as:

Mass Spectrometry LC-MS, LC-MS/MS and GC-MS

Mass spectrometry works by ionizing chemical compounds to generate charged molecules or molecule fragments and measuring their mass-to-charge ratios. The spectra are used to determine the elemental or isotopic signature of a sample, the masses of particles and of molecules, and to elucidate the chemical structures of molecules. Molecular weight confirmation is also applied in the identification and/or quantitation of solvents, identification of volatile impurities in starting materials and characterisation of synthesised intermediates, APIs and reference standards. 

Nuclear Magnetic Resonance (NMR)

Nuclear Magnetic Resonance is especially important in the structure analysis of organic compounds. Our Bruker 600 MHz, 400 MHz and 300 MHz Ultra-shield solution state spectrometers are capable of detecting 1H, 13C, 19F and 31P nuclei and are also capable of performing a suite of two-dimensional techniques for the structural elucidation/confirmation of your compounds.
Due to the direct correlation between the number of nuclei present and peak areas, NMR is also useful for the quantitation of compounds, whether this is for an assay determination of the material itself, a quantification of impurities and solvents or to measure levels of enantiomers/stereoisomers.

X-ray crystallography

X-ray crystallography is a useful tool for identifying the atomic and molecular structure of a crystal, in which the crystalline atoms cause a beam of incident X-rays to diffract into many specific directions. By measuring the intensities and angles of these diffracted beams, a crystallographer is capable of producing a 3D picture of the electron density within the crystal. From this electron density, the positions of the atoms in the crystal can be determined, as well as the chemical bonds, the disorder and various other information.


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