AM-0687 - CAS 1259522-94-5
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
AM-0687
Catalog Number:
1259522-94-5
Synonyms:
2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolinecarboxamide
CAS Number:
1259522-94-5
Description:
This active molecular is a selective PI3Kδ inhibitor. PI3Kδ is hyperactivated in B-cell malignancies and plays a vital role in the B-cell receptor pathway. AM-0687 has Cellular potency: pAKT IC50 = 0.7 nM; HWB, u (pAKT) IC 50 = 4.6 nM. AM-0687 shows excellent potency and selectivity profile in biochemical and cellular assays.
Molecular Weight:
442.46
Molecular Formula:
C23H19FN8O
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
O=C(C1=C(C2=NC=CC=C2)C([C@@H](NC3=NC=NC(N)=C3C#N)C)=NC4=CC=C(F)C=C14)NC
Targets:
PI3K

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