|Synonyms||2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid ADL 8-2698 ADL8-2698 alvimopan alvimopan anhydrous anhydrous alvimopan Entereg LY 246736 LY-246736 LY246736 trans-3,4-dimethyl-4-(3-hydroxyphenyl) pipe|
|Description||Alvimopan is a novel, oral, peripherally acting antagonist of the mu opioid receptor, which can help gastrointestinal recovery after surgery. Phase III IC50: Mu-type opioid receptor= 1.7 nM|
|Current Developer||Adolor Corporation; Cubist Pharmaceuticals|
JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ. It is an opioid analgesic dru...
Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.
Papaverine is an opiate alkaloid isolated from the plant Papaver somniferum. It is used primarily in the treatment of visceral spasm, vasospasm. It is also used...
Loperamide HCl is an opioid-receptor agonist with an ED50 of 0.15 mg/kg.
Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.
Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]-dihydromorphine binding with IC50 of 58 nM.
Odelepran is a opioid receptor antagonist. It is used for the treatment of alcohol dependence. It was developed by Lilly and was in clinical phase 2 trial, but ...
Bevenopran is a peripherally selective μ- and δ-opioid receptor antagonist. It is used for the treatment of chronic opioid-induced constipation. It was develope...
Nalfurafine is a selective and centrally-penetrant κ-opioid receptor (KOR) agonist without significant activity on μ- and δ-opioid receptors. With antipruritic ...
A 4-phenylpiperidine derivative, for the κ-opioid receptor.
Levallorphan, an allylmorphinan derivative, has been found to be a μ-opioid receptor antagonist that could be an analgesic agent as an prescription drug.
Met-Enkephalin is synthetic opioid peptides that has opioid effects of a relatively short duration.
The racemate form of TRV130 which is an oxaspiro compound that has been found to be a μ-opioid receptor G protein ligand and could be used in pain therapy.
Lexanopadol is a potent Opioid mu receptor agonist originated by Grunenthal. Lexanopadol is suited for the management of moderate to severe chronic pain, includ...
ADL5859 HCl is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel.
TRV130 is an oxaspiro compound that has been found to be a μ-opioid receptor G protein ligand and could be used in pain therapy. IC50: 8.1 (pEC50. G protein ass...
PZM-21 is a potent Gi activator which has selectivity for μOR. It is an experimental opioid analgesic drug promisingly used for the treatment of pain. Study ind...
Enadolineis a potent selective Opioid kappa receptor agonists originated by Pfizer. However, clinical trials for the treatment of Arrhythmias, Neuroprotection a...
The trihydrochloride salt form of MCOPPB, an effective full agonist of nociceptin receptor, could be a good antianxiety agent with few side-effects. pKi: 10.07.
LY2795050, a κ-opioid Receptor antagonist, has been found to be effective in imaging KOR behaving as a PET tracer. IC50: 0.72 nM and 25.8 nM for κ-opioid Recept...