Alvespimycin HCl - CAS 467214-21-7
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Alvespimycin HCl
Catalog Number:
467214-21-7
Synonyms:
17-DMAG HCl; NSC 707545; BMS 826476 HCl; KOS 1022.
CAS Number:
467214-21-7
Description:
Alvespimycin hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
Molecular Weight:
653.21
Molecular Formula:
C32H48N4O8•HCl
Quantity:
Grams-Kilos
Quality Standard:
In-house
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
InChI:
InChI=1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1
InChIKey:
DFSYBWLNYPEFJK-IHLRWNDRSA-N
Targets:
Hsp90 | HSP
Chemical Structure
CAS 467214-21-7 Alvespimycin HCl

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