Aluminum phthalocyanine chloride - CAS 14154-42-8
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Aluminum phthalocyanine chloride
Catalog Number:
14154-42-8
Synonyms:
Phthalocyanine Chloroaluminum; Chloroaluminum Phthalocyanine; Aluminum phthalocyanine chloride. Chloro(29H,31H-phthalocyaninato)aluminum;(SP-5-12)-chloro(29H,31H-phthalocyaninato(2-)-kappaN29,kappaN30,kappaN31,kappaN32)-Aluminum
CAS Number:
14154-42-8
Description:
Aluminum phthalocyanine chloride is an blue-green-coloured aromatic macrocyclic compound. It is widely used in dyeing. Phthalocyanine Chloroaluminum is a photosensitizer and it is useful in Photodynamic therapy (PDT).
Molecular Weight:
574.96
Molecular Formula:
C32H16AlClN8
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
C1=CC=C2C(=C1)C3=NC4=C5C=CC=CC5=C6N4[Al](N7C(=NC2=N3)C8=CC=CC=C8C7=NC9=NC(=N6)C1=CC=CC=C19)Cl
InChI:
InChI=1S/C32H16N8.Al.ClH/c1-2-10-18-17(9-1)25-33-26(18)38-28-21-13-5-6-14-22(21)30(35-28)40-32-24-16-8-7-15-23(24)31(36-32)39-29-20-12-4-3-11-19(20)27(34-29)37-25;;/h1-16H;;1H/q-2;+3;/p-1
InChIKey:
LBGCRGLFTKVXDZ-UHFFFAOYSA-M
Targets:
Others
Chemical Structure
CAS 14154-42-8 Aluminum phthalocyanine chloride

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Reference Reading


1.Highly Efficient Photodynamic Therapy Colloidal System Based On Chloroaluminum Phthalocyanine/Pluronic Micelles.
Py-Daniel KR1, Namban JS2, de Andrade LR1, de Souza PE2, Paterno LG3, Azevedo RB1, Soler MA4. Eur J Pharm Biopharm. 2016 Mar 24. pii: S0939-6411(16)30104-7. doi: 10.1016/j.ejpb.2016.03.028. [Epub ahead of print]
Phthalocyanine derivatives comprise the second generation of photosensitizer molecules employed in photodynamic therapy (PDT) and have attracted much attention due to their outstanding photosensitizing performance. Most phthalocyanines are hydrophobic compounds that require association to drug delivery systems for clinical use. In this study, formulations of Pluronic F127 micelles incorporated with chloroaluminum phthalocyanine, or else F127/AlClPc, were produced at optimized conditions aiming at efficient and biocompatible PDT colloidal systems. Absorption/emission spectroscopies, as well as dynamic light scattering were performed to evaluate the optimum conditions for the F127 micelle formation and AlClPc incorporation. The micelles formation was attained with F127 concentrations ranging from 50 to 150 mg mL-1. At these conditions, AlClPc photosensitizer molecules were encapsulated into the hydrophobic micelle core and, therefore, readily solubilized in physiological medium (PBS pH 7.
2.Reactive oxygen and nitrogen species disturb Ca(2+) oscillations in insulin-secreting MIN6 β-cells.
Antonucci S1,2, Tagliavini A3, Pedersen MG3. Islets. 2015 Jul 4;7(4):e1107255. doi: 10.1080/19382014.2015.1107255.
Disturbances in pulsatile insulin secretion and Ca(2+) oscillations in pancreatic β-cells are early markers of diabetes, but the underlying mechanisms are still incompletely understood. Reactive oxygen/nitrogen species (ROS/RNS) are implicated in reduced β-cell function, and ROS/RNS target several Ca(2+) pumps and channels. Thus, we hypothesized that ROS/RNS could disturb Ca(2+) oscillations and downstream insulin pulsatility. We show that ROS/RNS production by photoactivation of aluminum phthalocyanine chloride (AlClPc) abolish or accelerate Ca(2+) oscillations in the MIN6 β-cell line, depending on the amount of ROS/RNS. Application of the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase (SERCA) inhibitor thapsigargin modifies the Ca(2+) response to high concentrations of ROS/RNS. Further, thapsigargin produces effects that resemble those elicited by moderate ROS/RNS production. These results indicate that ROS/RNS interfere with endoplasmic reticulum Ca(2+) handling.
3.Photodynamic therapy leads to complete remission of tongue tumors and inhibits metastases to regional lymph nodes.
Bicalho LS1, Longo JP, Cavalcanti CE, Simioni AR, Bocca AL, Santos Mde F, Tedesco AC, Azevedo RB. J Biomed Nanotechnol. 2013 May;9(5):811-8.
In patients diagnosed with oral cancer, the most important prognostic indicator for patient survival after primary treatment is metastasis to the cervical lymph nodes or distal sites. Therefore, we evaluated the utility of photodynamic therapy (PDT) mediated by aluminum-chloride-phthalocyanine entrapped in liposomes for the prevention of metastasis to regional cervical lymph nodes in the Erhlich tongue cancer model. The PDT protocol led to complete remission of tongue tumours and prevented the occurrence of regional metastasis. The prevention of regional metastasis was confirmed by histopathological and immunohistochemical analyses. In addition, PDT treatment increased the overall survival and reduced weight loss relative to control tumour-bearing mice. Thus, PDT should be clinically evaluated for use in the prevention of cervical lymph node metastasis in patients with oral cancer.
4.The photosensitized oxidation of mixture of parabens in aqueous solution.
Gryglik D1, Gmurek M. Environ Sci Pollut Res Int. 2015 Jan 16. [Epub ahead of print]
The work presents results of studies on the photosensitized oxidation of mixture of five parabens (methyl-, ethyl-, propyl-, n-butyl-, and benzylparaben) in aqueous solution. Aluminum phthalocyanine chloride tetrasulfonic acid and xenon lamp simulating solar radiation were used as a photosensitizer and a light source, respectively. The purpose was to investigate the influence of inhibitory effect compounds present in the mixture on the reaction rate. The influence of the addition of second photosensitizer on the parabens degradation rate was investigated. The effect of additives: tert-butanol - hydroxyl radical scavenger and sodium azide - singlet oxygen scavenger on reaction course was also determined. The transformation products formed during the photosensitized oxidation process were analyzed by UPLC-MS/MS. The efficiency of photosensitized oxidation of parabens with natural sunlight irradiation in the central Poland was checked.