Aloin - CAS 1415-73-2
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Aloin
Catalog Number:
1415-73-2
Synonyms:
Barbaloin, Barbalin
CAS Number:
1415-73-2
Description:
Aloin, a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
Molecular Weight:
418.39
Molecular Formula:
C21H22O9
COA:
Inquire
MSDS:
Inquire
Targets:
Others
Chemical Structure
CAS 1415-73-2 Aloin

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Reference Reading


1.Aloin Inhibits IL-1β-Stimulated IL-8 Production in KB Cells.
Na HS1, Song YR1, Kim S1, Heo JY2, Chung HY3, Chung J1. J Periodontol. 2016 Mar 4:1-15. [Epub ahead of print]
BACKGROUND: IL-1β, which is elevated in oral diseases including gingivitis, stimulates epithelial cells to produce IL-8 and perpetuate inflammatory responses. This study was conducted to investigate the stimulatory effects of salivary IL-1β in IL-8 production and determine if aloin inhibits IL-1β-stimulated IL-8 production in epithelial cells.
2.In Silico Screening of Antibacterial Compounds from Herbal Sources Against Vibrio cholerae.
Perveen S1, Chaudhary HS1. Pharmacogn Mag. 2015 Oct;11(Suppl 4):S550-5. doi: 10.4103/0973-1296.172960.
BACKGROUND: The prolonged use of antibiotic viz., tetracycline, quinolones, ampicillin, etc., to reduce the infection of cholera, may failed due to the emergence of new Vibrio cholerae antibiotics resistant strains. Moreover, these antibiotics even restricted for patient suffering from severe dehydration. Hence, there is a call to find an alternative therapeutics against V. cholerae. The natures serve different herbs in its lap which might contain several natural therapeutic compounds almost all diseases. Computer-aided designing is the initial steps for screening the novel inhibitors.
3.NF-κB pathway inhibition by anthrocyclic glycoside aloin is key event in preventing osteoclastogenesis in RAW264.7 cells.
Pengjam Y1, Madhyastha H2, Madhyastha R2, Yamaguchi Y2, Nakajima Y2, Maruyama M3. Phytomedicine. 2016 Apr 15;23(4):417-28. doi: 10.1016/j.phymed.2016.01.006. Epub 2016 Feb 15.
BACKGROUND: Osteoporosis is a bone pathology leading to increased fracture risk and challenging the quality of life. As current treatments can exhibit deleterious side effects, the use of phyto-compounds with therapeutic and preventive activities against orthopaedic related problems represents a promising alternative.
4.Protective effects of aloin on oxygen and glucose deprivation-induced injury in PC12 cells.
Chang R1, Zhou R1, Qi X1, Wang J1, Wu F1, Yang W1, Zhang W1, Sun T2, Li Y3, Yu J4. Brain Res Bull. 2016 Mar;121:75-83. doi: 10.1016/j.brainresbull.2016.01.001. Epub 2016 Jan 6.
The present study aims to determine whether aloin could protect cells from ischemic and reperfusion injury in vitro and to elucidate the related mechanisms. Oxygen and glucose deprivation model in PC12 cells was used in the present study. 2-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH) assay and Hoechst 33342 nuclear staining were used to evaluate the protective effects of aloin, at concentrations of 10, 20, or 40μg/mL in PC12 cells. PCR was applied to detect fluorescence caspase-3, Bax and Bcl-2 mRNA expression in PC12 cells. The contents of malondialdehyde (MDA), superoxide dismutase (SOD) activity were evaluated by biochemical method. The concentration of intracellular-free calcium [Ca(2+)]i, mitochondrial membrane potential (MMP) were determined to estimate the degree of neuronal damage. It was shown that aloin (10, 20, and 40μg/mL) significantly attenuated PC12 cells damage with characteristics of an increased injured cells absorbance of MTT and releases of LDH, decreasing cell apoptosis, and antagonizing decreases in SOD activity and increase in MDA level induced by OGD-reoxygenation.