Alizapride - CAS 59338-93-1
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Alizapride
Catalog Number:
59338-93-1
Synonyms:
N-(1-allyl-2-pyrrolidinylmethyl)-6-methoxy-1h-benzotriazole-5-carboxamide;1H-benzotriazole-5-carboxamide,6-methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)met;6-Methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-1h-benzotriazole-5-carbo;6-Methoxy-N-{[1-(2-propny
CAS Number:
59338-93-1
Description:
Alizapride is a dopamine antagonist. It has prokinetic and antiemetic effects and is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. It is structurally related to metoclopramide and other benzamides. It has been listed.
Molecular Weight:
315.37
Molecular Formula:
C16H21N5O2
Quantity:
Grams to Kilograms
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
COC1=CC2=NNN=C2C=C1C(=O)NCC3CCCN3CC=C
InChI:
InChI=1S/C16H21N5O2/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20)
InChIKey:
KSEYRUGYKHXGFW-UHFFFAOYSA-N
Targets:
Dopamine Receptor
Current Developer:
Alizapride has been listed.
Chemical Structure
CAS 59338-93-1 Alizapride

Related Dopamine Receptor Products


CAS 104632-26-0 Pramipexole

Pramipexole
(CAS: 104632-26-0)

Pramipexole (Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

CAS 84-02-6 Prochlorperazine Dimaleate

Prochlorperazine Dimaleate
(CAS: 84-02-6)

Prochlorperazine is a dopamine D2 receptor antagonist. It belongs to the phenothiazine class of antipsychotic agents and can be used for the antiemetic treatmen...

PD-120697
(CAS: 108351-91-3)

PD-120697 is a novel dopamine antagonist with central dopamine agonist properties. It was identified as orally active dopamine (DA) agonists with pronounced cen...

NS-2359
(CAS: 195875-68-4)

NS-2359, a serotonin-norepinephrine-dopamine reuptake inhibitor, may be able to reduce cocaine withdrawal symptoms, reduce cocaine craving and reduce cocaine-in...

SB269652
(CAS: 215802-15-6)

SB269652, an allosteric modulator of D2R, consists of a tetrahydroisoquinoline pharmacophore bound in the OBS and an indole-2-carboxamide moiety bound in a SBP ...

CAS 24526-64-5 Nomifensine

Nomifensine
(CAS: 24526-64-5)

Nomifensine, also called as Hoe 984 or Linamiphen, as a norepinephrine-dopamine reuptake inhibitor it is an antidepressant drug but due to increased incidence o...

CAS 125572-93-2 Rotigotine Hydrochloride

Rotigotine Hydrochloride
(CAS: 125572-93-2)

The hydrochloride salt form of Rotigotine which is a dopamine D2 and D3 receptor agonist and has been shown to be effective in the treatment of Parkinson's dise...

CAS 1649-18-9 Azaperone

Azaperone
(CAS: 1649-18-9)

Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary...

ABT670
(CAS: 630119-43-6)

ABT670 is a drug which acts as a potent, superior orally bioavailable dopamine agonist selective for the D4 subtype. It was used as a possible treatment for ere...

ML398 hydrochloride
(CAS: 1379510-21-0)

ML398 is potent dopamine 4 receptor antagonist with IC50 value of 130 nM and Ki of 36 nM. It exhibits no activity against the other dopamine receptors tested (>...

Aplindore Fumarate
(CAS: 189681-71-8)

Aplindore Fumarate is a partial agonist selective for the dopamine receptor D2 used in the therapeutic treatment of Parkinson Disease and restless legs syndrome...

CAS 41372-20-7 (R)-Apomorphine Hydrochloride Hemihydrate

(R)-Apomorphine Hydrochloride Hemihydrat
(CAS: 41372-20-7)

(R)-Apomorphine is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.

CAS 53583-79-2 Barnetil

Barnetil
(CAS: 53583-79-2)

Barnetil acts as a selective D2 and D3 receptor antagonist, which has high affinity for these receptors of dissociation constants of 2.2 nM and 2.4 nM respectiv...

CAS 170381-16-5 Zicronapine

Zicronapine
(CAS: 170381-16-5)

Zicronapine, an inden derivative, has been found to be neurotransmitter receptor modulators of sorts of neurotransmitter and was studied against Schizophrenia.

CAS 117-89-5 trifluoperazine

trifluoperazine
(CAS: 117-89-5)

Trifluoperazine is a typical antipsychotic of the phenothiazine chemical class with anti-adrenergic and anti-dopaminergic actions just similar to Chlorpromazine...

CAS 1098-60-8 Triflupromazine Hydrochloride

Triflupromazine Hydrochloride
(CAS: 1098-60-8)

The hydrochloride salt form of Triflupromazine, an analogue of Chlorpromazine, is effective as nntipsychotic drug and antemetic agent.

CAS 52-86-8 Haloperidol

Haloperidol
(CAS: 52-86-8)

Haloperidol (Haldol) is an antipsychotic and butyrophenone.

CAS 54143-57-6 Metoclopramide hydrochloride hydrate

Metoclopramide hydrochloride hydrate
(CAS: 54143-57-6)

Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist used to treat nausea and vomitin.

Nolomirole hydrochloride
(CAS: 138531-51-8)

Nolomirole is a Alpha 2 adrenergic receptor and Dopamine D2 receptor agonist. Nolomirole can attenuate the heart failure signs in the monocrotaline-induced cong...

CAS 122883-93-6 Ziprasidone Hydrochloride

Ziprasidone Hydrochloride
(CAS: 122883-93-6)

The hydrochloride salt form of Ziprasidone which is an antagonism of both serotonin and dopamine receptor and could be effective against schizophrenia.

Reference Reading


1.Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.
Horta ML1, Morejon LC, da Cruz AW, Dos Santos GR, Welling LC, Terhorst L, Costa RC, Alam RU. Br J Anaesth. 2006 Jun;96(6):796-800. Epub 2006 Apr 5.
BACKGROUND: We have compared the use of alizapride, propofol, droperidol and promethazine for the prevention of spinal morphine-induced pruritus.
2.The benefits and risks of different therapies in preventing postoperative nausea and vomiting in patients undergoing thyroid surgery.
Fujii Y1. Curr Drug Saf. 2008 Jan;3(1):27-34.
Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events of anesthesia and surgery, with a relatively high incidence following thyroidectomy. These symptoms predispose to aspiration of gastric contents, increased intraocular pressure, psychological distress, and delayed recovery and discharge times. Numerous antiemetics have been studied for the prevention and treatment of PONV following thyroidectomy. These drugs include butyrophenones (e.g., droperidol), benzamides (e.g., metoclopramide), antihistamines (e.g., dimenhydrinate), corticosteroids (e.g., dexamethasone), propofol, oxygen, and serotonon receptor antagonists (e.g., ondansetron). Most of published trials indicate improved prophylaxis against PONV by avoiding risk factors and/or by using effective antiemetic therapy in patients scheduled for thyroid surgery. Traditional antiemetics (droperidol, metoclopramide, and alizapride), non-traditional antiemetics (propofol and dexamethasone), and serotonin receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron, and ramosetron) have been studied for the prevention of PONV.
3.Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products.
Tamaro I1, Aprile S, Giovenzana GB, Grosa G. J Pharm Biomed Anal. 2010 Apr 6;51(5):1024-31. doi: 10.1016/j.jpba.2009.10.026. Epub 2009 Nov 6.
A stability-indicating high-performance liquid chromatography procedure has been developed for the determination of alizapride (AL) and its main degradation products alizapride carboxylic acid (AL-CA) and alizapride N-oxide (AL-NO2) in drug substance and product. The method was developed based on forced degradation data obtained by HPLC-MS analysis. Indeed AL underwent chemical degradation by acid/base catalyzed hydrolysis and oxidation the main degradation products being AL-CA and AL-NO2 respectively. The separation and quantisation were achieved on a 150-mm reverse phase column with a hydrophilic linkage between silica particles and hydrophobic alkyl chains. The mobile phase was constituted (flow rate 1.5mLmin(-1)) of eluant A: aqueous acetate buffer (pH 4.0; 20mM) and eluant B: CH(3)OH using a gradient elution and detection of analytes at 225nm. The method showed good linearity for the AL, AL-CA, AL-NO2 mixture in the 25-75, 1-15 and 1-15microgmL(-1) ranges respectively, being all the square of the correlation coefficients greater than 0.