Alizapride - CAS 59338-93-1
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Alizapride
Catalog Number:
59338-93-1
Synonyms:
N-(1-allyl-2-pyrrolidinylmethyl)-6-methoxy-1h-benzotriazole-5-carboxamide;1H-benzotriazole-5-carboxamide,6-methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)met;6-Methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-1h-benzotriazole-5-carbo;6-Methoxy-N-{[1-(2-propny
CAS Number:
59338-93-1
Description:
Alizapride is a dopamine antagonist. It has prokinetic and antiemetic effects and is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. It is structurally related to metoclopramide and other benzamides. It has been listed.
Molecular Weight:
315.37
Molecular Formula:
C16H21N5O2
Quantity:
Grams to Kilograms
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
COC1=CC2=NNN=C2C=C1C(=O)NCC3CCCN3CC=C
InChI:
InChI=1S/C16H21N5O2/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20)
InChIKey:
KSEYRUGYKHXGFW-UHFFFAOYSA-N
Targets:
Dopamine Receptor
Current Developer:
Alizapride has been listed.
Chemical Structure
CAS 59338-93-1 Alizapride

Related Dopamine Receptor Products


Amisulpride hydrochloride
(CAS: 81342-13-4)

Amisulpride hydrochloride could inhibit radioligand binding to native dopamine D2 receptor in membranes from the rat striatum with an IC50 value of 21nM. It has...

Haloperidol hydrochloride
(CAS: 1511-16-6)

Haloperidol hydrochloride is a dopamine antagonist that specifically targets D2-like receptors, with effect to treat schizophrenia, acute psychosis, and deliriu...

CAS 66104-23-2 Pergolide Mesylate

Pergolide Mesylate
(CAS: 66104-23-2)

Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.

CAS 32795-47-4 Nomifensine maleate

Nomifensine maleate
(CAS: 32795-47-4)

Nomifensine maleate is maleate salt form of Nomifensine. Nomifensine, also called as Hoe 984 or Linamiphen, as a norepinephrine-dopamine reuptake inhibitor it i...

CAS 327026-93-7 Lensiprazine

Lensiprazine
(CAS: 327026-93-7)

Lensiprazine is a potent in vitro dopamine receptor antagonist and highly active as serotonin reuptake inhibitor.

Brexpiprazole
(CAS: 913611-97-9)

Brexpiprazole, a novel atypical antipsychotic drug, is a D2 dopamine partial agonist called serotonin-dopamine activity modulator (SDAM). It is approved for the...

CAS 346688-38-8 Pridopidine

Pridopidine
(CAS: 346688-38-8)

Pridopidine, also known as ACR16, is a dopamine stabilizer used in the treatment of neurologic and psychiatric disorders.

CAS 5786-21-0 Clozapine

Clozapine
(CAS: 5786-21-0)

Clozapine is an atypical antipsychotic drug by acting as a 5-HT antagonist, used in the treatment of schizophrenia.

CAS 117-89-5 trifluoperazine

trifluoperazine
(CAS: 117-89-5)

Trifluoperazine is a typical antipsychotic of the phenothiazine chemical class with anti-adrenergic and anti-dopaminergic actions just similar to Chlorpromazine...

ABT 925 Fumerate
(CAS: 220519-07-3)

A 437203 is a selective dopamine (DA) D3 receptor antagonist suited to evaluate the physiological role(s) of D3 receptors. A 437203 shows an approximately 100-f...

CAS 34161-24-5 Fipexide hydrochloride

Fipexide hydrochloride
(CAS: 34161-24-5)

Fipexide hydrochloride is a nootropic agent that displays a positive effect on cognitive function

JPC-211
(CAS: 82668-33-5)

JPC-211 is a selective dopamine D3 receptor agonist.

CAS 69-23-8 Fluphenazine

Fluphenazine
(CAS: 69-23-8)

Fluphenazine, sold under the brand names Prolixin

Adrogolide Hydrochloride
(CAS: 166591-11-3)

The hydrochloride salt form of Adrogolide,a quinoline derivative, has been found to be a dopamine D1 receptor agonist that was once studied in Parkinson's disea...

CAS 16562-13-3 L-Stepholidine

L-Stepholidine
(CAS: 16562-13-3)

L-Stepholidine, naturally occured herbal constituent of Stephania intermedia, with the potential to treat neural diseases including dyskinesia, parkinsonism, sc...

CAS 104632-27-1 Pramipexole impurity D

Pramipexole impurity D
(CAS: 104632-27-1)

The dihydrochloride salt form of dexpramipexole, also known as R-(+)-Pramipexole, is one of the impurities of pramipexole. It coule be used as a negative contro...

CAS 23672-07-3 Levosulpiride

Levosulpiride
(CAS: 23672-07-3)

Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.Levosulpiride is used in the treatment of psycho...

PD-119819
(CAS: 105277-43-8)

PD-119819, a heterocyclic piperazine, is an extremely selective DA autoreceptor agonist. It binds [3H]haloperidol in tests in rats. It inhibits of spontaneous l...

CAS 146939-27-7 Ziprasidone

Ziprasidone
(CAS: 146939-27-7)

Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist like other atypical antipsychotic agents. Ziprasidone targets dopamine neurotransmis...

CAS 125572-93-2 Rotigotine Hydrochloride

Rotigotine Hydrochloride
(CAS: 125572-93-2)

The hydrochloride salt form of Rotigotine which is a dopamine D2 and D3 receptor agonist and has been shown to be effective in the treatment of Parkinson's dise...

Reference Reading


1.Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.
Horta ML1, Morejon LC, da Cruz AW, Dos Santos GR, Welling LC, Terhorst L, Costa RC, Alam RU. Br J Anaesth. 2006 Jun;96(6):796-800. Epub 2006 Apr 5.
BACKGROUND: We have compared the use of alizapride, propofol, droperidol and promethazine for the prevention of spinal morphine-induced pruritus.
2.The benefits and risks of different therapies in preventing postoperative nausea and vomiting in patients undergoing thyroid surgery.
Fujii Y1. Curr Drug Saf. 2008 Jan;3(1):27-34.
Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events of anesthesia and surgery, with a relatively high incidence following thyroidectomy. These symptoms predispose to aspiration of gastric contents, increased intraocular pressure, psychological distress, and delayed recovery and discharge times. Numerous antiemetics have been studied for the prevention and treatment of PONV following thyroidectomy. These drugs include butyrophenones (e.g., droperidol), benzamides (e.g., metoclopramide), antihistamines (e.g., dimenhydrinate), corticosteroids (e.g., dexamethasone), propofol, oxygen, and serotonon receptor antagonists (e.g., ondansetron). Most of published trials indicate improved prophylaxis against PONV by avoiding risk factors and/or by using effective antiemetic therapy in patients scheduled for thyroid surgery. Traditional antiemetics (droperidol, metoclopramide, and alizapride), non-traditional antiemetics (propofol and dexamethasone), and serotonin receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron, and ramosetron) have been studied for the prevention of PONV.
3.Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products.
Tamaro I1, Aprile S, Giovenzana GB, Grosa G. J Pharm Biomed Anal. 2010 Apr 6;51(5):1024-31. doi: 10.1016/j.jpba.2009.10.026. Epub 2009 Nov 6.
A stability-indicating high-performance liquid chromatography procedure has been developed for the determination of alizapride (AL) and its main degradation products alizapride carboxylic acid (AL-CA) and alizapride N-oxide (AL-NO2) in drug substance and product. The method was developed based on forced degradation data obtained by HPLC-MS analysis. Indeed AL underwent chemical degradation by acid/base catalyzed hydrolysis and oxidation the main degradation products being AL-CA and AL-NO2 respectively. The separation and quantisation were achieved on a 150-mm reverse phase column with a hydrophilic linkage between silica particles and hydrophobic alkyl chains. The mobile phase was constituted (flow rate 1.5mLmin(-1)) of eluant A: aqueous acetate buffer (pH 4.0; 20mM) and eluant B: CH(3)OH using a gradient elution and detection of analytes at 225nm. The method showed good linearity for the AL, AL-CA, AL-NO2 mixture in the 25-75, 1-15 and 1-15microgmL(-1) ranges respectively, being all the square of the correlation coefficients greater than 0.