Alipamide - CAS 3184-59-6
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Alipamide
Catalog Number:
3184-59-6
Synonyms:
Alipamide;Alipamidum;4-Chloro-N',N'-dimethyl-3-sulfamoylbenzohydrazide;Alipamid;CI-546;D-1721;2-chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide
CAS Number:
3184-59-6
Description:
Alipamide is a bio-active chemical with a sequence-specific threading tetra-intercalator with an extremely slow dissociation rate constant.
Molecular Weight:
277.03
Molecular Formula:
C9H12CLN3O3S
Quantity:
Milligrams-Grams
Quality Standard:
Enterprise standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CN(C)NC(=O)C1=CC(=C(C=C1)Cl)S(=O)(=O)N
InChI:
1S/C9H12ClN3O3S/c1-13(2)12-9(14)6-3-4-7(10)8(5-6)17(11,15)16/h3-5H,1-2H3,(H,12,14)(H2,11,15,16)
InChIKey:
NJYBZXINKWROMG-UHFFFAOYSA-N
Targets:
Others
Chemical Structure
CAS 3184-59-6 Alipamide

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Reference Reading


1.A sequence-specific threading tetra-intercalator with an extremely slow dissociation rate constant.
Holman GG1, Zewail-Foote M, Smith AR, Johnson KA, Iverson BL. Nat Chem. 2011 Sep 25;3(11):875-81. doi: 10.1038/nchem.1151.
A long-lived and sequence-specific ligand-DNA complex would make possible the modulation of biological processes for extended periods. For this purpose, we are investigating a polyintercalation approach to DNA recognition in which flexible chains of aromatic units thread back and forth repeatedly through the double helix. Here we describe the DNA-binding behaviour of a threading tetra-intercalator. Specific binding was observed on a relatively long DNA strand that strongly favoured a predicted 14 base-pair sequence. Kinetic studies revealed a multistep association process, with sequence specificity that primarily derives from large differences in dissociation rates. The rate-limiting dissociation rate constant of the tetra-intercalator complex dissociating from its preferred binding site was extremely slow, corresponding to a half-life of 16 days. This is one of the longest non-covalent complex half-lives yet reported and, to the best of our knowledge, the longest for a DNA-binding molecule.
2.Self-assembly of interlocked supramolecular dendrimers.
Jeong KS1, Park EJ. J Org Chem. 2004 Apr 2;69(7):2618-21.
Interlocked supramolecular dendrimers were spontaneously self-assembled from molecular components, metallocycles, and dumbbells bearing benzyl ether repeating units. Here, the metallocycles were in situ self-assembled from L-shaped ligands with dendritic branches, 2,3-dimethyl-2-butene and osmium tetraoxide. The supramolecular dendrimers were stabilized by hydrogen-bonding interactions between the pyridine-2,6-dicarboxamide unit in the metallocycle and the adipamide unit in the dumbbell.
3.Permeation properties of poly(m-xylene adipamide) membranes.
Buquet CL1, Doudou BB, Chappey C, Dargent E, Marais S. J Phys Chem B. 2009 Mar 19;113(11):3445-52. doi: 10.1021/jp810241z.
The permeation properties of a semiaromatic polyamide, the poly(m-xylene adipamide) (MXD6), were investigated by water and carbon dioxide permeation experiments (pervaporation and gas permeation tests). Complementary microstructure informations were obtained from calorimetric measurements. Amorphous and semicrystalline MXD6 membranes were studied. The analysis of the water flux through amorphous MXD6 membranes showed a plasticization phenomenon followed by a water-induced crystallization. It resulted that the role played by water in these materials was complex because of the dependence of the water diffusivity on water concentration and time. Because of the presence of crystalline phase, a significant reduction of water and gas permeability of MXD6 and an increase in the delay of diffusion were observed. In terms of barrier properties for water and carbon dioxyde, MXD6 membrane crystallized at high temperature were more performant than water-induced crystallized ones.