Aldoxorubicin - CAS 151038-96-9
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Aldoxorubicin
Catalog Number:
151038-96-9
Synonyms:
DOXO-EMCH, INNO-206, INNO206; INNO 206; Aldoxorubicin
CAS Number:
151038-96-9
Description:
Aldoxorubicin, also known as INNO-206,  is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Following intravenous administration, doxorubicin prodrug INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hyervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity.
COA:
Inquire
MSDS:
Inquire
Targets:
Antibody-drug Conjugates
Current Developer:
Innovive Pharmaceuticals and CytRx Corporation
Chemical Structure
CAS 151038-96-9 Aldoxorubicin

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