Albiflorin - CAS 39011-90-0
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Albiflorin
Catalog Number:
39011-90-0
CAS Number:
39011-90-0
Description:
Albiflorin is a major constituent presents in peony root, which possesses therapeutic potential for neurodegenerative diseases.
Molecular Weight:
480.46
Molecular Formula:
C23H28O11
COA:
Inquire
MSDS:
Inquire
Targets:
Others
Chemical Structure
CAS 39011-90-0 Albiflorin

Related Products


CAS 90-01-7 2-Hydroxybenzyl alcohol

2-Hydroxybenzyl alcohol
(CAS: 90-01-7)

2-Hydroxybenzyl alcohol could be extracted from salix bark. And this is the reason for 2-Hydroxybenzyl alcohol being named "Salicyl alcohol". It is an precursor...

CAS 949021-68-5 Sodium formononetin-3(acute)-sulfonate

Sodium formononetin-3(acute)-sulfonate
(CAS: 949021-68-5)

Sodium formononetin-3'-sulfonate is a water-sol. derivate of formononetin. It has a protective potential against myocardial infarction injury. It not only had f...

CAS 23007-85-4 MPTP hydrochloride

MPTP hydrochloride
(CAS: 23007-85-4)

A dopaminergic neurotoxin that causes permanent symptoms of Parkinson's disease by killing certain neurons in the substantia nigra of the brain. Useful tool com...

SID 3712249
(CAS: 522606-67-3)

SID 3712249 is an biogenesis of microRNA-544 (miR-544) inhibitor caused apoptosis in triple negative breast cancer cells.

CC-17368
(CAS: 1547162-41-3)

CC-17368, a hydroxyisoindole derivative, is a metabolites of pomalidomide and has potential activity in anticancer study like multiple myeloma.

CAS 137-58-6 Lidocaine

Lidocaine
(CAS: 137-58-6)

Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

CAS 1260075-17-9 PKR-IN-1

PKR-IN-1
(CAS: 1260075-17-9)

Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it...

Amifampridine Phosphate
(CAS: 446254-47-3)

Amifampridine is a drug, predominantly used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, ...

CAS 489-32-7 Icariin

Icariin
(CAS: 489-32-7)

Icariin is a flavonol glycoside, a type of flavonoid. Icariin is a PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.

CAS 36861-47-9 4-Methylbenzylidene camphor

4-Methylbenzylidene camphor
(CAS: 36861-47-9)

4-Methylbenzylidene camphor (4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, speci...

CAS 57-08-9 6-Acetamidohexanoic acid

6-Acetamidohexanoic acid
(CAS: 57-08-9)

6-Acetamidohexanoic acid is used in inhibiting the Gastrointestinal disease like gastric ulcer or small bowel inflammation. It is often used after some oral adm...

FR-168888 Free Base
(CAS: 168620-45-9)

The free base of FR-168888, a guanidine compound, has been found to be a sodium hydrogen antiporter inhibitor that was once studied in myocardial ischaemia ther...

CAS 4350-09-8 L-5-Hydroxytryptophan

L-5-Hydroxytryptophan
(CAS: 4350-09-8)

L-5-Hydroxytryptophan is an intermediate in the biosynthesis of serotonin from tryptophan.

CAS 149003-01-0 Dexrazoxane hydrochloride

Dexrazoxane hydrochloride
(CAS: 149003-01-0)

Dexrazoxane hydrochloride is an intracellular iron chelator, which decreases the formation of superoxide radicals, used as a cardioprotective agent.

CAS 22910-60-7 Ginkgolic Acid

Ginkgolic Acid
(CAS: 22910-60-7)

Ginkgolic Acid is a natural compound with suspected cytotoxic, allergenic, mutagenic and carcinogenic properties.

CAS 55750-63-5 EMCS

EMCS
(CAS: 55750-63-5)

ECMS is a useful protective group in antibody drug conjugates as a ADCs Linker.

CAS 53-84-9 NAD+

NAD+
(CAS: 53-84-9)

NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It plays a role in the activity of...

CAS 481-46-9 Ginkgetin

Ginkgetin
(CAS: 481-46-9)

Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L. According to reports, it has anti-inflammatory and anti-cancer effects.

CAS 41060-15-5 Neobavaisoflavone

Neobavaisoflavone
(CAS: 41060-15-5)

Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40,...

CAS 7432-28-2 Schisandrin

Schisandrin
(CAS: 7432-28-2)

Schisandrin has various therapeutic effects on a range of medical conditions such as anti-asthmatic, anti-cancer, and anti-inflammatory effects.

Reference Reading


1.Calcium Channels Contribute to Albiflorin-mediated Antinociceptive Effects in Mouse Model.
Zhang Y1, Sun D2, Meng Q3, Guo W4, Chen Q4, Zhang Y5. Neurosci Lett. 2016 Mar 30. pii: S0304-3940(16)30200-2. doi: 10.1016/j.neulet.2016.03.054. [Epub ahead of print]
Albiflorin (AF), one of important bioactive constituents of Paeonia lactiflora Radix, possesses neuro-protective effect. The present study aims to investigate the antinociceptive activities of AF and possible mechanisms. AF suppressed acetic acid-caused writhing, lengthened the latency period of mouse in hot plate test, and reduced the licking and biting response time of the injected mouse paw during phase I and phase II, and it suggested that AF exerted the antinociceptive activity mainly through central nervous system. Nimodipine, a commonly used calcium channels blocker, strongly lengthened AF-enhanced latency period of mouse in hot plate test. Compared with control group, AF reduced the levels of euronal nitric oxide synthase (nNOS), and enhanced the levels of serotonin (5-HT) in serum and/or hypothalamus before and after 30-s thermal stimuli. The reduced activation of calmodulin-dependent protein kinase II and c-Jun N-terminal kinase in hypothalamus was observed in AF-treated mice.
2.Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats.
Song J1, Hou X1, Hu X2, Lu C1, Liu C1, Wang J1, Liu W2, Teng L1, Wang D3. Chem Biol Interact. 2015 Dec 5;242:211-7. doi: 10.1016/j.cbi.2015.10.001. Epub 2015 Oct 22.
Albiflorin (AF), separated from the root of Paeonia lactiflora Pall, possesses neuro-protective and anti-inflammatory activities. Based on previous results, our present research aims to investigate the antidepressant-like activity of AF in chronic unpredictable mild stress (CUMS)-induced rat model of depression. Eight weeks of CUMS process successfully established depression-like rat model, as evidenced by the enhanced immobility time in forced swimming test and the reduced sucrose preference, which were reversed to near normal by AF (20 mg/kg and 40 mg/kg) and fluoxetine (3 mg/kg; positive drug) treated. Compared to non-treated depression-like rats, the increased levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HTAA) in serum and hypothalamus, and the reduced expressions of 5-HT1A receptor and 5-HT2A receptor in hypothalamus were observed after AF and fluoxetine oral administration indicating that AF-mediated antidepressant-like effect may be related to the normalization of serotonergic system.
3.Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats.
Song J1, Hou X1, Hu X2, Lu C1, Liu C1, Wang J1, Liu W2, Teng L1, Wang D3. Chem Biol Interact. 2015 Dec 5;242:211-7. doi: 10.1016/j.cbi.2015.10.001. Epub 2015 Oct 22.
Albiflorin (AF), separated from the root of Paeonia lactiflora Pall, possesses neuro-protective and anti-inflammatory activities. Based on previous results, our present research aims to investigate the antidepressant-like activity of AF in chronic unpredictable mild stress (CUMS)-induced rat model of depression. Eight weeks of CUMS process successfully established depression-like rat model, as evidenced by the enhanced immobility time in forced swimming test and the reduced sucrose preference, which were reversed to near normal by AF (20 mg/kg and 40 mg/kg) and fluoxetine (3 mg/kg; positive drug) treated. Compared to non-treated depression-like rats, the increased levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HTAA) in serum and hypothalamus, and the reduced expressions of 5-HT1A receptor and 5-HT2A receptor in hypothalamus were observed after AF and fluoxetine oral administration indicating that AF-mediated antidepressant-like effect may be related to the normalization of serotonergic system.
4.Calcium Channels Contribute to Albiflorin-mediated Antinociceptive Effects in Mouse Model.
Zhang Y1, Sun D2, Meng Q3, Guo W4, Chen Q4, Zhang Y5. Neurosci Lett. 2016 Mar 30. pii: S0304-3940(16)30200-2. doi: 10.1016/j.neulet.2016.03.054. [Epub ahead of print]
Albiflorin (AF), one of important bioactive constituents of Paeonia lactiflora Radix, possesses neuro-protective effect. The present study aims to investigate the antinociceptive activities of AF and possible mechanisms. AF suppressed acetic acid-caused writhing, lengthened the latency period of mouse in hot plate test, and reduced the licking and biting response time of the injected mouse paw during phase I and phase II, and it suggested that AF exerted the antinociceptive activity mainly through central nervous system. Nimodipine, a commonly used calcium channels blocker, strongly lengthened AF-enhanced latency period of mouse in hot plate test. Compared with control group, AF reduced the levels of euronal nitric oxide synthase (nNOS), and enhanced the levels of serotonin (5-HT) in serum and/or hypothalamus before and after 30-s thermal stimuli. The reduced activation of calmodulin-dependent protein kinase II and c-Jun N-terminal kinase in hypothalamus was observed in AF-treated mice.