ALB 109564(a) dihydrochloride - CAS 1300114-12-8
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
ALB 109564(a) dihydrochloride
Catalog Number:
1300114-12-8
Synonyms:
Vincaleukoblastine 12(methylthio) hydrochloride (1:2);(3aR,3a1R,4R,5S,5aR,10bR)-methyl 4-acetoxy-3a-ethyl-9-((3S,5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-13-(methylthio)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate
CAS Number:
1300114-12-8
Description:
ALB 109564(a) is a Tubulin inhibitor as a semi-synthetic derivative of the vinka alkaloid originated by AMRI. It can bind to tubulin monomers and inhibit microtubule formation, this leads to the disruption of mitotic spindle assembly and arrest of tumor cells in the G2/M phase of the cell cycle. Phase I clinical trials for Solid tumours is on going.
Molecular Weight:
930.00
Molecular Formula:
C47-H60-N4-O9-S.2Cl-H
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC[C@@]1(C[C@H]2C[C@@](c3c(c4cc(ccc4[nH]3)SC)CC[N@](C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)OC)O)OC(=O)C)CC)C)C(=O)OC)O.Cl.Cl
InChI:
1S/C47H60N4O9S.2ClH/c1-9-43(55)23-28-24-46(41(53)58-6,37-30(14-18-50(25-28)26-43)31-20-29(61-8)12-13-34(31)48-37)33-21-32-35(22-36(33)57-5)49(4)39-45(32)16-19-51-17-11-15-44(10-2,38(45)51)40(60-27(3)52)47(39,56)42(54)59-7;;/h11-13,15,20-22,28,38-40,48,55-
InChIKey:
MTABGSVEFKMZFG-USKOTZBXSA-N
Targets:
Microtubule/Tubulin
Current Developer:
Originator AMRI

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