|Product Name||Akt1 and Akt2-IN-1|
|Description||Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 and Akt2 with the IC50 of 3.5 nM and 42 nM respectively. It has potent and balanced activity. It is dependent on the PH-domain for Akt inhibition. It is selective for Akt1/2 over Akt3 and is highly selective over other members of the AGC family of kinases in vitro. It has potent inhibitory activity against Akt1 and Akt 2 in vivo in a mouse lung and efficacy in a tumor xenograft model. It has moderate activity in an hERG binding assay and is a substrate for human P-glycoprotein. It also shows good physical properties with a human plasma protein binding.|
|Quality Standard||In-house standard|
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AKT Kinase Inhibitor
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Akt1 and Akt2-IN-1
Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 and Akt2 with the IC50 of 3.5 nM and 42 nM respectively. It has potent and balanced activity. It is depend...
AKT inhibitor VIII
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SC66 is a novel and potent AKT inhibitor, which reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in...
Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane...
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