AKBA - CAS 67416-61-9
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
AKBA
Catalog Number:
67416-61-9
Synonyms:
Acetyl-11-keto-β-boswellic acid
CAS Number:
67416-61-9
Description:
AKBA is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.
Molecular Weight:
512.72
Molecular Formula:
C32H48O5
COA:
Inquire
MSDS:
Inquire
Targets:
Others
Chemical Structure
CAS 67416-61-9 AKBA

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Reference Reading


1.Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage.
Catanzaro D1, Rancan S1, Orso G2, Dall'Acqua S1, Brun P3, Giron MC1, Carrara M1, Castagliuolo I3, Ragazzi E1, Caparrotta L1, Montopoli M1. PLoS One. 2015 May 8;10(5):e0125375. doi: 10.1371/journal.pone.0125375. eCollection 2015.
Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission and often serious side effects. Meanwhile complementary and alternative medicine (CAM) use is increasing, particularly herbal medicine. Boswellia serrata is a traditional Ayurvedic remedy with anti-inflammatory properties, of interest for its usefulness in IBDs. The mechanism of this pharmacological potential of Boswellia serrata was investigated in colonic epithelial cell monolayers exposed to H2O2 or INF-γ+TNF-α, chosen as in vitro experimental model of intestinal inflammation. The barrier function was evaluated by the transepithelial electrical resistance (TEER) and paracellular permeability assay, and by the tight junction proteins (zonula occludens-1, ZO-1 and occludin) immunofluorescence. The expression of phosphorylated NF-κB and reactive oxygen species (ROS) generation were determined by immunoblot and cytofluorimetric assay, respectively.
2.Bioavailability enhancement of a BCS IV compound via an amorphous combination product containing ritonavir.
Miller DA1, Keen JM1, Brough C1,2, Ellenberger DJ1,2, Cisneros M1, Williams RO 3rd2, McGinity JW2. J Pharm Pharmacol. 2015 Oct 10. doi: 10.1111/jphp.12478. [Epub ahead of print]
OBJECTIVES: To evaluate the effect of ritonavir (RTV) co-administration on the bioavailability of an amorphous dispersion of acetyl-11-keto-beta-boswellic acid (AKBA) and to develop a pharmaceutically acceptable AKBA-RTV combination tablet.
3.Development and optimisation of 3-Acetyl-11-keto-β-boswellic acid loaded poly-lactic-co-glycolic acid-nanoparticles with enhanced oral bioavailability and in-vivo anti-inflammatory activity in rats.
Bairwa K1, Jachak SM1. J Pharm Pharmacol. 2015 Sep;67(9):1188-97. doi: 10.1111/jphp.12420. Epub 2015 Apr 7.
OBJECTIVES: 3-Acetyl-11-keto-β-boswellic acid (AKBA) is a potent anti-inflammatory compound of Boswellia serrata. However, anti-inflammatory activity of AKBA is impeded by poor oral bioavailability due to its poor aqueous solubility. In this context, we aimed to develop poly lactic-co-glycolic acid (PLGA)-based nanoparticle formulation of AKBA (AKBA-NPs) in order to improve its oral bioavailability and in-vivo anti-inflammatory activity in rats.
4.Boswellia carterii liquisolid systems with promoted anti-inflammatory activity.
Mostafa DM, Ammar NM, Abd El-Alim SH1, Kassem AA, Hussein RA, Awad G, El-Awdan SA. Curr Drug Deliv. 2015;12(4):454-63.
<i>Boswellia carterii</i> (BC) Birdwood oleogum resin is an ancient remedy of inflammation processes known since Ancient Egyptian time. Of boswellic acids, 3-acetyl-11-keto-β-boswellic acid (AKBA) is the most potent anti-inflammatory active principle. Liquisolid systems of the biologically active fraction of BC oleogum resin were prepared for improving dissolution properties using low dose oral delivery to achieve enhanced anti-inflammatory activity, in comparison with the standard oral anti-inflammatory; Indomethacin. AKBA was assayed, employing an accurate and sensitive HPLC method. Detection was carried out at 210 nm using UV/Vis detector. A solubility study for the bioactive fraction was conducted. Microcrystalline cellulose and Aeroperl®300 Pharma were used as carrier and coating materials. Angle of slide, liquid load factor and Carr's flow index were estimated. Six systems were prepared using polyethylene glycol 400, solvent and two drug loading concentrations; 20 and 40 %.