AHU-377 hemicalcium salt - CAS 1369773-39-6
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
AHU-377 hemicalcium salt
Catalog Number:
1369773-39-6
Synonyms:
Sacubitril hemicalcium salt; AHU377 hemicalcium salt; AHU 377 hemicalcium salt
CAS Number:
1369773-39-6
Description:
LCZ696 is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). Oral administration of LCZ696 caused dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provided sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats. In healthy participants, a randomized, double-blind, placebo-controlled study (n = 80) of single-dose (200-1200 mg) and multiple-dose (50-900 mg once daily for 14 days) oral administration of LCZ696 showed that peak plasma concentrations were reached rapidly for valsartan (1.6-4.9 hours), AHU377 (0.5-1.1 hours), and its active moiety, LBQ657 (1.8-3.5 hours). LCZ696 is superior to valsartan alone in reducing blood pressure. Preliminary results from a Phase II trial showed that LCZ696 reduced NT-proBNP to a greater extent than valsartan alone, and in addition LCZ696 had beneficial effects on symptoms.
Molecular Weight:
410.48
Molecular Formula:
C24H28NO5-
COA:
Inquire
MSDS:
Inquire
Targets:
Neprilysin
Chemical Structure
CAS 1369773-39-6 AHU-377 hemicalcium salt

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