AGN 194310 - CAS 229961-45-9
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
AGN 194310
Catalog Number:
229961-45-9
Synonyms:
AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310
CAS Number:
229961-45-9
Description:
A high affinity pan-RAR antagonist (AGN194310, K(d) for binding to RARs = 2-5 nM) inhibited colony formation (by 50%) by all three lines at 16-34 nM, and led to a transient accumulation of flask-cultured cells in G1 followed by apoptosis. AGN194310 is 12-22 fold more potent than all-trans retinoic acid (ATRA) against cell lines and also more potent in inhibiting the growth of primary prostate carcinoma cells. The administration of all-trans retinoic acid to VAD mice resulted in a transient reduction in NF-kappaB activity and, conversely, a single dose of the RAR-pan-antagonist, AGN 194310, administered to control mice, led to a marked, transient induction of whole-body luminescence. Mice were treated with AGN194310, a synthetic retinoid that antagonises the physiological function of the three RAR isotypes (alpha, beta, gamma) but does not interact with RXRs. Analyses of the granulocytic lineage using Gr-1, c-Kit and CD11b antibodies, demonstrated that granulocyte numbers were strikingly increased across haemopoietic compartments in all AGN194310-treated mice. A significant increase in the frequency of progenitor cells containing granulocytes was observed in the bone marrow of mice following treatment with AGN194310.
Molecular Weight:
424.55
Molecular Formula:
C28H24O2S
COA:
Inquire
MSDS:
Inquire
Targets:
RAR/RXR
Chemical Structure
CAS 229961-45-9 AGN 194310

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