|Product Name||AG 126|
|Synonyms||2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile， Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile;|
|Description||Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK（growth factor receptor kinases）. The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α ( tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG-126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM . AG-126 may represent a new approach for the therapy of inflammation.|
|Quality Standard||In-house standard|
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