AG 126 - CAS 118409-62-4
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
AG 126
Catalog Number:
118409-62-4
Synonyms:
2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile, Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile;
CAS Number:
118409-62-4
Description:
Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK(growth factor receptor kinases). The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α ( tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG-126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM . AG-126 may represent a new approach for the therapy of inflammation.
Molecular Weight:
215.16
Molecular Formula:
C10H5N3O3
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]
InChI:
InChI=1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H
InChIKey:
DUQADSPERJRQBW-UHFFFAOYSA-N
Targets:
Ser/Thr Protease
Chemical Structure
CAS 118409-62-4 AG 126

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