AF 353 - CAS 865305-30-2
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
AF 353
Catalog Number:
865305-30-2
Synonyms:
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-;Ro 4;5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine
CAS Number:
865305-30-2
Description:
AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats.
Molecular Weight:
400.21
Molecular Formula:
C14H17IN4O2
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC
InChI:
InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19)
InChIKey:
AATPYXMXFBBKFO-UHFFFAOYSA-N
Targets:
P2X Receptor
Chemical Structure
CAS 865305-30-2 AF 353

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