AEW-541 - CAS 475489-16-8
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
AEW-541
Catalog Number:
475489-16-8
Synonyms:
NVP-AEW541; AEW541; AEW 541.
CAS Number:
475489-16-8
Description:
AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP-AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. NVP-AEW541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application.
COA:
Inquire
MSDS:
Inquire
Targets:
IGF-1R
Current Developer:
Novartis Pharmaceuticals
Chemical Structure
CAS 475489-16-8 AEW-541

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