Adolezesin - CAS 110314-48-2
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Adolezesin
Catalog Number:
110314-48-2
Synonyms:
U73975;U-73975;N-(2-((7bR,8aS)-7-methyl-4-oxo-1,2,4,5,8,8a-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-2-carbonyl)-1H-indol-5-yl)benzofuran-2-carboxamide
CAS Number:
110314-48-2
Description:
Adozelesin is an experimental antitumor drug of the duocarmycin class. It is the first of a class of DNA-sequence-selective alkylating agents. It binds to and alkylates DNA, resulting in a reduction of both cellular and simian virus 40 (SV40) DNA replication which ultimately reduces the rate of cancer growth. It has marginal efficacy in the treatment of metastatic breast cancer at the dosage and schedule used in clinic phase 1 and 2 trials. It was developed by Pharmacia and was terminated in clinic phase 2 trials.
Molecular Weight:
502.52
Molecular Formula:
C30H22N4O4
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC1=CNC2=C1C34CC3CN(C4=CC2=O)C(=O)C5=CC6=C(N5)C=CC(=C6)NC(=O)C7=CC8=CC=CC=C8O7
InChI:
InChI=1S/C30H22N4O4/c1-15-13-31-27-22(35)11-25-30(26(15)27)12-18(30)14-34(25)29(37)21-9-17-8-19(6-7-20(17)33-21)32-28(36)24-10-16-4-2-3-5-23(16)38-24/h2-11,13,18,31,33H,12,14H2,1H3,(H,32,36)/t18-,30+/m1/s1
InChIKey:
BYRVKDUQDLJUBX-JJCDCTGGSA-N
Targets:
Others
Current Developer:
Adozelesin was developed by Pharmacia and was terminated in clinic phase 2 trials.
Chemical Structure
CAS 110314-48-2 Adolezesin

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