|Description||Adozelesin is an experimental antitumor drug of the duocarmycin class. It is the first of a class of DNA-sequence-selective alkylating agents. It binds to and alkylates DNA, resulting in a reduction of both cellular and simian virus 40 (SV40) DNA replication which ultimately reduces the rate of cancer growth. It has marginal efficacy in the treatment of metastatic breast cancer at the dosage and schedule used in clinic phase 1 and 2 trials. It was developed by Pharmacia and was terminated in clinic phase 2 trials.|
|Quality Standard||In-house standard|
|Current Developer||Adozelesin was developed by Pharmacia and was terminated in clinic phase 2 trials.|
Furaltadone HCl is an antibacterial and has distinct curative effect in the treatment of coccidiosis.
This active moleculr is a Os(II) anticancer drug candidate. It can generate reactive oxygen species and disrupt the redox balance in cancer cells. Using FY26 an...
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a prefe...
Cardiogenol c hydrochloride
The hydrochloride salt form of Cardiogenol C, a pyrimidine derivative, might be able to induce embryonic stem cells (ESCs) into cardiomyocytes. It is significan...
Ginkgolide B is a PAFR antagonist with IC50 of 3.6 μM.
Ocaphane Hydrochloride is a strong antitumor agent used on a number of animal tumors such as Brown-Pearce carcinoma but is fairly toxic to hemopoietic organs.
Gypenoside XVII is a natural product extracted from the roots of Panax notoginseng (Burk.) F.H.Chen. It confers protection against Aβ25-35-induced neurotoxicity...
This molecular is a novel non-peptide tachykinin NK3 receptor antagonist and it has a very high affinity for native guinea pig (pK(i) value 7.8) tachykinin NK(3...
PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor. DprE1 is an essential enzyme involved in the cell wall biosynthesis of Corynebacterineae. The...
(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.
CFLZ-171 formic acid salt
CFLZ-171 is an important intermediate to synthesis carfilzomib which is an anti-cancer drug acting as a selective proteasome inhibitor.
AKBA is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.
Mulberroside A, extracted from the root bark of white mulberry, could reduce P-gp expression and function being along with the activation of PKC and NF-κB. It h...
Cgp 13143 is a bio-active chemical,but no detailed information has been published yet.
L-Arginine HCl (L-Arg)
L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
Mitotane, is an antineoplastic medication used in the treatment of adrenocortical carcinoma.
Quinine is a primary alkaloid of various species of Cinchona. Because of its relatively constant and well-known fluorescence quantum yield, quinine is also used...
SE inhibitor NB-598 significantly inhibited both basal and glucose-stimulated insulin secretion from mouse pancreatic islets. CaV channels were markedly inhibit...
Heparin, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological...
Created by the enzyme protoporphyrinogen oxidase, protoporphyrin IX is an important precursor to biologically essential prosthetic groups.