|Synonyms||1-[(2,4-dichlorophenyl)methyl]indazole-3-carbohydrazide 1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide adjudin AF-2364 AF2364|
|Description||Adjudin, formerly called as AF-2364, an analog of lonidamine， attenuates microglia activation by suppression of the NF-κB pathway. Adjudin has potent anti-spermatogenic activity in animals.|
CID-2858522 selectively inhibits the NF-κB pathway induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activ...
Emodin is a naturally occurring anthraquinone present in the roots and barks of numerous plants. It exerts antiproliferative effects in cancer cells that are re...
Harpagoside, isolated from the Harpagophytum procumbens (Devil's Claw) root or Crophularia ningpoensis Hemsl (Figwort), inhibited lipopolysaccharide-induced mRN...
Sodium salicylate is used in medicine as an analgesic and antipyretic.
Recoflavone, also referred to DA 6034, is a synthetic flavonoid derivative known to possess anti-inflammatory activity in phase Ⅲ clinical trials for the treatm...
Didox, synthetic antioxidant, is a strong inhibitor of ribonucleotide reductase (RR) that has been found to reduce the levels of oxidative injury markers in the...
Edasalonexent, also known as CAT-1004, is a NF-kappa B inhibitor under the development of Catabasis Pharmaceuticals and Sarepta Therapeutics. It is a Inflammati...
QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.
PNRI-299 is a selective AP-1 transcription inhibitor without affecting NF-kappaB transcription or thioredoxin.
Adjudin, formerly called as AF-2364, an analog of lonidamine， attenuates microglia activation by suppression of the NF-κB pathway. Adjudin has potent anti-sperm...
Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor, inducing apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells...
Prostratin is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). I...
JSH-23 is a nuclear factor-kappa B (NF-κB) nuclear translocation inhibitor. JSH-23 inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of...
Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
Eupatilin, isolated from the leaves of Artemisia argyi Levl.et Vant, inhibits the signalling of MAPK, IKK, NF-κB and eotaxin-1 in bronchial epithelial cells, le...
Oleandrin, also known as PBI-05204, is a lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically bin...
Methysticin, the first Kava-pyrone isolated from the active constituents of rhizome extracts from Piper methysticum-a shrub indigenous to South Pacific islands,...
Lipoic Acid, an organosulfur compound, is widely used as dietary supplements and antioxidant. It has been also found to influence the activity of nuclear factor...