1.Electrochemical biosensor for simultaneous determination of guanine and adenine based on dopamine-melanin colloidal nanospheres–graphene composites
Hai-Bo Wang & Hong-Ding Zhang & Lu-Lu Xu. J Solid State Electrochem (2014) 18:2435–2442
Deoxyribonucleic acid (DNA) is an important biological macromolecule which plays a crucial role in the storage of genetic information and protein biosynthesis. Guanine (G) and adenine (A) are two important purine bases existed in DNA, which play fundamental roles in life process. They have participated in processes as distinct as energy transduction, metabolic cofactors, and cell signaling. The abnormal changes of
the bases in organism suggest the deficiency and mutation of the immunity system and may indicate the presence of various diseases including cancer, epilepsy, and HIV infection. Moreover, their concentration levels are considered as important parameter for diagnosis of cancers, AIDS, myocardial cellular energy status, disease progress, and therapy responses. Therefore, the determination of guanine and adenine is of great significance for clinical diagnosis as well as insight into fundamental mechanisms of genetic information.
2.Temperature-dependent THz vibrational spectra of clenbuterol hydrochloride
YANG YuPing*, LEI XiangYun, YUE Ai & ZHANG ZhenWei. SCIENCE CHINA Physics, Mechanics & Astronomy. April 2013 Vol.56 No.4: 713–717
At liquid N2 temperature (77 K), it can be noted that the broad absorption features seen at 295 K undergoes a pronounced sharpening, and another two weak peaks visible at about 1.860 and 2.446 THz. These line-narrowing effect and peak-splitting phenomenon have also been observed in genistein and biochanin A, purine and adenine, aspirin and aspirin precursor, as well as a number of small biological molecules.
3.Isolation of adenine salts in the gas phase from a liquid beam of aqueous solutions by IR laser irradiation
J.-Y. Kohno, F. Mafune, and T. Kondow. Eur. Phys. J. D 20, 339–345 (2002)
We have developed a method that molecules in a liquid beam are isolated from a liquid beam under irradiation of an IR laser having a wavelength resonant to a OH stretching vibration of liquid water. In the present study, we applied this method to isolate adenine salts (probably adenine di-hydrochloride and sodium adeninate) from a liquid beam of aqueous acidic and alkaline solutions of adenine under irradiation of an IR laser (Scheme 1). The isolated adenine salts are ionized in the gas phase by a UV laser. We discussed the two different mechanisms of the isolation and the ionization of the adenine salts.