Ademetionine - CAS 29908-03-0
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Ademetionine
Catalog Number:
29908-03-0
Synonyms:
S-Adenosyl-L-methionine; S-Adenosyl methionine; SAMe; AdoMet
CAS Number:
29908-03-0
Description:
S-adenosyl-l-methionine (SAMe) is a naturally-occurring substance which is a major source of methyl groups in the brain. The efficacy of SAMe in treating depressive syndromes and disorders is superior with that of placebo and comparable to that of standard tricyclic antidepressants. Since SAMe is a naturally occurring compound with relatively few side-effects, it is a potentially important treatment for depression. S-adenosylmethionine (SAMe) is a dietary supplement used in the management of osteoarthritis (OA) symptoms. Studies evaluating SAMe in the management of OA have been limited to Non Steroidal Anti-inflammatory Drugs (NSAIDs) for comparison. The present study compares the effectiveness of SAMe to a cyclooxygenase-2 (COX-2) inhibitor (celecoxib) for pain control, functional improvement and to decrease side effects in people with osteoarthritis of the knee.
Molecular Weight:
398.44
Molecular Formula:
C15H22N6O5S
COA:
Inquire
MSDS:
Inquire
Targets:
Others
Chemical Structure
CAS 29908-03-0 Ademetionine

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Reference Reading


1.Pharmacodynamic studies on the central mode of action of S-adenosyl-L-methionine (SAMe) infusions in elderly subjects, utilizing EEG mapping and psychometry
B. Saletu, P. Anderer, L. Linzmayer. J Neural Transm (2002) 109: 1505–1526
S-adenosyl-L-methionine (SAMe), or ademetionine, a naturally occurring molecule, is found in all living organisms. In humans, it is distributed throughout virtually all body tissues and fluids, with highest concentrations in childhood, decreasing with age. Synthesized from methionine and adenosine triphosphate (ATP) in a reaction catalyzed by methionine adenosyltransferase (MAT), SAMe acts as a major methyl donor in enzymatic transmethylation reactions (Stramentinoli, 1987). Moreover, through transsulfuration it is a precursor of essential amino acids including cysteine, taurine and glutathione (Friedel et al., 1989). Via transmethylation, methyl groups (-CH3) are transferred by SAMe to various molecules, such as nucleic acids, proteins, phospholipids, hormones, neurotransmitters, catecholamines and other biogenic amines. Phospholipids, which are integral constituents of biological membranes, play a crucial role in many membrane functions such as iron transport, receptoreffector coupling, secretion of biogenic amines etc. (Baldessarini, 1987; Stramentinoli, 1987). That is why transmethylation, an essential step in the biosynthesis of phospholipids, has a major impact on physicochemical properties of membranes like fluidity and consequently affects important functions such as receptor-effector coupling (Hirata and Axelrod, 1980). With age, the methylation process of phospholipids is attenuated, which reduces the fluidity of the membranes and thus the efficiency of the beta-adrenergic receptors. SAMe intake in elderly people has been proved to prevent this decrease of the methylation process in membranes.