|Synonyms||S-Adenosyl-L-methionine; S-Adenosyl methionine; SAMe; AdoMet|
|Description||S-adenosyl-l-methionine (SAMe) is a naturally-occurring substance which is a major source of methyl groups in the brain. The efficacy of SAMe in treating depressive syndromes and disorders is superior with that of placebo and comparable to that of standard tricyclic antidepressants. Since SAMe is a naturally occurring compound with relatively few side-effects, it is a potentially important treatment for depression. S-adenosylmethionine (SAMe) is a dietary supplement used in the management of osteoarthritis (OA) symptoms. Studies evaluating SAMe in the management of OA have been limited to Non Steroidal Anti-inflammatory Drugs (NSAIDs) for comparison. The present study compares the effectiveness of SAMe to a cyclooxygenase-2 (COX-2) inhibitor (celecoxib) for pain control, functional improvement and to decrease side effects in people with osteoarthritis of the knee.|
This active molecular is a reversible and selective platelet P2Y12 receptor antagonist. IC50 value of ACT-246475 is 8.0 nM. ACT-246475 dose-dependently blocked ...
Sanguinarine caused cell death in a dose dependent manner in all neuroblastoma cell lines except SK-N-BE(2) with rates of 18% in SH-SY5Y and 21% in Kelly human ...
Mecarbinate is a chemical intermediate of arbidol hydrochloride.
Cardiogenol c hydrochloride
The hydrochloride salt form of Cardiogenol C, a pyrimidine derivative, might be able to induce embryonic stem cells (ESCs) into cardiomyocytes. It is significan...
Deferasirox effectively chelates iron from Rhizopus oryzae and demonstrates cidal activity in vitro against 28 of 29 clinical isolates of Mucorales at concentra...
Extract from Carthamin, widely used for the treatment of acute ischemic stroke by acting directly on BV2 microglia.
IPD is an alkylsulfonate DNA crosslinker.
FR-190809 is a potent and orally efficacious ACAT inhibitor potentially for the treatment of Lipoprotein Disorders.
Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation a...
Cloquintocet-mexyl is a herbicide. It is used to control coarse annual grass of the family poaceae (gramineae). lt was developed by the swiss ciba geigy in the ...
Ono-1082 increases cAMP levels in hepatocytes in rats.
The hydrochloride salt form of L-Propionylcarnitine which has been found to be related to mitochondrial metabolism so that could be used in the treatment deteri...
Tetrahydrouridine, a derivative of Uridine, is a potent and reversible competitive inhibitor of cytidine deaminase (CDD) (Ki values = 54 and 240 nM for human an...
Bevantolol is a beta-1 adrenoceptor antagonist has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension
This active molecular is a bio-active chemical and detailed information has not been published yet
Xylitol is a chemical categorized as a polyalcohol or sugar alcohol (alditol). It is an achiral isomer of pentane-1,2,3,4,5-pentol. It is used as a diabetic swe...
Foresaconitine is a norditerpenoid alkaloid isolated from the processed tubers of Aconitum carmichaeli.
Deferoxamine mesylate, an iron chelator, could be used in the treatment of acute iron poisoning, sickle cell diseases and it is also found to have some extent o...
Heparin sodium is a sodium salt of heparin which is a naturally-occurring anticoagulant used for anticoagulation for cardiovascular disease.