Ademetionine - CAS 29908-03-0
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Ademetionine
Catalog Number:
29908-03-0
Synonyms:
S-Adenosyl-L-methionine; S-Adenosyl methionine; SAMe; AdoMet
CAS Number:
29908-03-0
Description:
S-adenosyl-l-methionine (SAMe) is a naturally-occurring substance which is a major source of methyl groups in the brain. The efficacy of SAMe in treating depressive syndromes and disorders is superior with that of placebo and comparable to that of standard tricyclic antidepressants. Since SAMe is a naturally occurring compound with relatively few side-effects, it is a potentially important treatment for depression. S-adenosylmethionine (SAMe) is a dietary supplement used in the management of osteoarthritis (OA) symptoms. Studies evaluating SAMe in the management of OA have been limited to Non Steroidal Anti-inflammatory Drugs (NSAIDs) for comparison. The present study compares the effectiveness of SAMe to a cyclooxygenase-2 (COX-2) inhibitor (celecoxib) for pain control, functional improvement and to decrease side effects in people with osteoarthritis of the knee.
Molecular Weight:
398.44
Molecular Formula:
C15H22N6O5S
COA:
Inquire
MSDS:
Inquire
Targets:
Others
Chemical Structure
CAS 29908-03-0 Ademetionine

Related Products


CAS 6055-19-2 Cyclophosphamide Monohydrate

Cyclophosphamide Monohydrate
(CAS: 6055-19-2)

Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA. It is used to treat cancers and aut...

CAS 709-98-8 Propanil

Propanil
(CAS: 709-98-8)

Propanil is a widely used contact herbicide mainly used to control weed growth in rice fields.

KHK-IN-1 hydrochloride
(CAS: 1303470-48-5)

The hydrochloride salt form of KHK-IN-1 which is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on Asp-27B in...

AZD-5423
(CAS: 1034148-04-3)

AZD-5423 is a nonsteroidal glucocorticoid. It is used to treat respiratory diseases and in particular chronic obstructive pulmonary disease. It was developed by...

NK-1145 Hydrochloride
(CAS: 16487-37-9)

The hydrochloride salt form of NK-1145, an azabicyclo derivative, has been found to be a parasympatholytic drug that could induce stimulation and excitement.

Cgp 13143
(CAS: 75919-69-6)

Cgp 13143 is a bio-active chemical,but no detailed information has been published yet.

CAS 6106-24-7 Disodium tartrate dihydrate

Disodium tartrate dihydrate
(CAS: 6106-24-7)

Disodium tartrate dihydrate is a Acid phosphatase inhibitor used in buffers for molecular biology and cell culture applications.

CAS 21738-42-1 Oxamniquine

Oxamniquine
(CAS: 21738-42-1)

Oxamniquine, with schistosomicidal activity, is an antischistosomal drug used in the treatment of Schistosoma mansoni infection.

CAS 103300-74-9 Taltirelin Acetate

Taltirelin Acetate
(CAS: 103300-74-9)

Taltirelin Acetate is used in the treatment of spinocerebellar degeneration.Synthetic thyrotropin-releasing hormone (TRH) analog.

CAS 112111-45-2 (R)-(-)-Modafinic acid

(R)-(-)-Modafinic acid
(CAS: 112111-45-2)

(R)-(-)-Modafinic acid(Armodafinic acid) is the major metabolite of Modafinil(HY-10521A), which is a central nervous system vigilance promoting agent, which pos...

OT-R antagonist 2
(CAS: 364071-16-9)

OT-R antagonist 2 is a nonpeptide OT-R antagonist, inhibitis IP3-Synthesis, rat OT-R (IC50 = 0.33 μM).

CAS 33620-72-3 Britannilactone

Britannilactone
(CAS: 33620-72-3)

A bioassay-guided isolation of the chloroform fraction of the I. britannica using an in vitro melanogenesis inhibition assay led to the isolation of sesquiterpe...

CAS 222030-63-9 Fosbretabulin

Fosbretabulin
(CAS: 222030-63-9)

Fosbretabulin, also called as CA4P, has antitumor activity against anaplastic thyroid cancer (ATC) cell lines. Fosbretabulin, a novel water-soluble vascular-dis...

CAS 483-34-1 (-)-Isocorypalmine

(-)-Isocorypalmine
(CAS: 483-34-1)

(-)-Isocorypalmine is a alkaloid, as a metabolite of the isoquinoline.

CAS 442201-24-3 Remogliflozin etabonate

Remogliflozin etabonate
(CAS: 442201-24-3)

Remogliflozin etabonat, pro-drug of remogliflozin, is a SGLT2 inhibitor under development for the treatment of type 2 diabetes. Remogliflozin etabonate is a pr...

E-982
(CAS: 858102-78-0)

CP-60949-4
(CAS: 17518-97-7)

CP-60949-4, a quinazolin derivative, could be probably useful in sorts of biological studies.

CAS 4871-97-0 Curcumol

Curcumol
(CAS: 4871-97-0)

Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.

CAS 739-71-9 trimipramine

trimipramine
(CAS: 739-71-9)

Trimipramine is a tricyclic antidepressant. It is serotonin and norepinephrine transport inhibitor with antipsychotic and sedative properties.

CAS 520-45-6 Dehydroacetic acid

Dehydroacetic acid
(CAS: 520-45-6)

Dehydroacetic acid is a pyrone derivative used mostly as a fungicide and bactericide.

Reference Reading


1.Pharmacodynamic studies on the central mode of action of S-adenosyl-L-methionine (SAMe) infusions in elderly subjects, utilizing EEG mapping and psychometry
B. Saletu, P. Anderer, L. Linzmayer. J Neural Transm (2002) 109: 1505–1526
S-adenosyl-L-methionine (SAMe), or ademetionine, a naturally occurring molecule, is found in all living organisms. In humans, it is distributed throughout virtually all body tissues and fluids, with highest concentrations in childhood, decreasing with age. Synthesized from methionine and adenosine triphosphate (ATP) in a reaction catalyzed by methionine adenosyltransferase (MAT), SAMe acts as a major methyl donor in enzymatic transmethylation reactions (Stramentinoli, 1987). Moreover, through transsulfuration it is a precursor of essential amino acids including cysteine, taurine and glutathione (Friedel et al., 1989). Via transmethylation, methyl groups (-CH3) are transferred by SAMe to various molecules, such as nucleic acids, proteins, phospholipids, hormones, neurotransmitters, catecholamines and other biogenic amines. Phospholipids, which are integral constituents of biological membranes, play a crucial role in many membrane functions such as iron transport, receptoreffector coupling, secretion of biogenic amines etc. (Baldessarini, 1987; Stramentinoli, 1987). That is why transmethylation, an essential step in the biosynthesis of phospholipids, has a major impact on physicochemical properties of membranes like fluidity and consequently affects important functions such as receptor-effector coupling (Hirata and Axelrod, 1980). With age, the methylation process of phospholipids is attenuated, which reduces the fluidity of the membranes and thus the efficiency of the beta-adrenergic receptors. SAMe intake in elderly people has been proved to prevent this decrease of the methylation process in membranes.