Adarotene - CAS 496868-77-0
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Adarotene
Catalog Number:
496868-77-0
Synonyms:
ST1926; ST 1926; ST-1926.
CAS Number:
496868-77-0
Description:
Adarotene is an atypical retinoid and a promising anti-tumour agent with selective apoptotic activity on the leukaemic blast. The anti-tumour activity of the compound has been associated with its capacity to induce DNA double stranded breaks.
COA:
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MSDS:
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Targets:
Apoptosis Inducer
Chemical Structure
CAS 496868-77-0 Adarotene

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Reference Reading


1.New retinoid derivatives as back-ups of Adarotene.
Giannini G1, Brunetti T, Battistuzzi G, Alloatti D, Quattrociocchi G, Cima MG, Merlini L, Dallavalle S, Cincinelli R, Nannei R, Vesci L, Bucci F, Foderà R, Guglielmi MB, Pisano C, Cabri W. Bioorg Med Chem. 2012 Apr 1;20(7):2405-15. doi: 10.1016/j.bmc.2012.01.042. Epub 2012 Feb 6.
Adarotene belongs to the so-called class of atypical retinoids. The presence of the phenolic hydroxyl group on Adarotene structure allows a rapid O-glucuronidation as a major mechanism of elimination of the drug, favoring a fast excretion of its glucuronide metabolite in the urines. A series of ether, carbamate and ester derivatives was synthesized. All of them were studied and evaluated for their stability at different pH. The cytotoxic activity in vitro on NCI-H460 non-small cell lung carcinoma and A2780 ovarian tumor cell lines was also tested. A potential back-up of Adarotene has been selected to be evaluated in tumor models.