Acumapimod - CAS 836683-15-9
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Acumapimod
Catalog Number:
836683-15-9
Synonyms:
BCT 197; BCT197A2201;3-(5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide
CAS Number:
836683-15-9
Description:
Acumapimod is a P38 mitogen-activated protein kinase inhibitor with IC50 value of less than 1 μM for p38α. Phase II clinical trials for the treatment of Chronic obstructive pulmonary disease are on-going.
Molecular Weight:
385.42
Molecular Formula:
C22-H19-N5-O2
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
Cc1ccc(cc1n2c(c(cn2)C(=O)c3cccc(c3)C#N)N)C(=O)NC4CC4
InChI:
1S/C22H19N5O2/c1-13-5-6-16(22(29)26-17-7-8-17)10-19(13)27-21(24)18(12-25-27)20(28)15-4-2-3-14(9-15)11-23/h2-6,9-10,12,17H,7-8,24H2,1H3,(H,26,29)
InChIKey:
VGUSQKZDZHAAEE-UHFFFAOYSA-N
Targets:
p38 MAPK
Current Developer:
Mereo BioPharma; Novartis

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