|Synonyms||BCT 197; BCT197A2201;3-(5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide|
|Description||Acumapimod is a P38 mitogen-activated protein kinase inhibitor with IC50 value of less than 1 μM for p38α. Phase II clinical trials for the treatment of Chronic obstructive pulmonary disease are on-going.|
|Quality Standard||In-house standard|
|Current Developer||Mereo BioPharma; Novartis|
SB 203580 hydrochloride
SB 203580 hydrochloride is a water-soluble form of the potent MAP kinase inhibitor SB 203580. It is a selective inhibitor of p38 mitogen-activated protein kinas...
p38 MAPK-IN-1, a naphthyridine N-oxide, is a novel potent and selective inhibitor of p38 MAPK and it was found to have proper balance between potency and pharma...
Talmapimod, also known as SCIO-469, is an orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodula...
VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that ...
Losmapimod is a promising new agent against cardiovascular diseases. This drug works by inhibiting p38 MAP kinases, which play an important role in the developm...
Doramapimod (BIRB 796) is a member of the N-pyrazole-N'-naphthly urea class of p38MAPK inhibitors, which binds to the kinase with both slow association and diss...
PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase. PH-797804 exhibited exceptionally high specificity against MAP kinases ...
UPC-K-005 is a novel small-molecule inhibitor of a new allosteric site in p38α (IC50 = 13 mcM), which is the binding site for MAPK-activated protein kinase 2 (M...
SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 uM.
SB239063 is a potent p38MAPK inhibitor. SB 239063 had an IC(50) of 44 nM for inhibition of recombinant purified human p38alpha. In lipopolysaccharide-stimulated...
SB202190, also named FHPI, under the IUPAC name 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one, is a pyridinyl imid...
AMG-548 is a selective p38α inhibitor with Ki value of 0.5nM. It displays >1000-fold selectivity against 36 other kinases, and it can inhibit whole blood LPS-st...
Acumapimod is a P38 mitogen-activated protein kinase inhibitor with IC50 value of less than 1 μM for p38α. Phase II clinical trials for the treatment of Chronic...
SD-06 is an inhibitor of p38α (IC50=170 nM).
RPR-200765A Mesylayte, a potent and selective inhibitor of p38 MAP kinase (IC50 = 50 nM), could exhibit a profile of disease modifying activity in rheumatoid ar...
CHMFL-ABL-053 is a potent and orally available inhibitor of BCR-ABL (IC50 = 70nM) without inhibitory activity against c-KIT kinase that is a common target of BC...
TA-02 is a p38 MAPK inhibitor ( IC50 = 20 nM ).
LY2228820 dimesylate is a highly selective small molecule inhibitor of p38α(IC50=7 nM) and p38β mitogen-activated protein kinases (MAPKs).