|Description||This molecular is a prodrug of ACT-246475 which is a selective P2Y12 receptor antagonist with a wider therapeutic window in the rat model. ACT-281959 is the phosphate of ACT-246475 and showed antithrombotic efficacy after oral administration in the rat ferric chloride model. In May 2016, Phase-I development is ongoing in France.|
|Quality Standard||In-house standard|
|Current Developer||Originator:Actelion Pharmaceuticals|
ML281, a quinoxalin derivative, has been found to be a STK33 inhibitor and could have probable effect against KRAS-dependent cancers. IC50: 14 nM.
ISO-1 is an inhibitor of the dopachrome tautomerase activity of MIF. It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and impr...
Bucetin, a phenacetin analog, has antipyretic and analgesic effect. It has been discontinued for showing renal toxicity.
A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transf...
UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC5...
Fenofibric acid is a lipid regulating agent available as delayed release capsules for oral administration.
Erdosteine is a mucolytic which is used in treatment of excessive viscous mucus.
N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast.
Exogenous H2S, as we know, has anti-inflammatory effects both in macrophages and in animal models. FW1256 is a slow release H2S dononr and it is much more poten...
LY-79771 is a antiobesity agent. It can be effective in preventing fat regain following energy deprivation.
Cinoctramide is an intermediate of pharmaceutical synthesis.
RG7800 is a selective Survival of motor neuron 1 protein (SMN1) stimulant and Survival of motor neuron 2 protein (SMN2) modulator originated by Roche. RG7800 sh...
ATR-101 is a selective Acetyl CoA C-acetyltransferase inhibitor. ATR-101 is uniquely distributed to adrenal tissues and inhibition of adrenal ACAT1 by ATR-101 d...
AM-2159 is a bio-active chemical, but no detailed information has been published yet.
Bulleyaconitine A, an active indegrent from aconitum bulleyanum Diel, has been found to be effective in the treatment of chronic pain and rheumatoid arthritis.
Cgp 8716 is a major metabolite of GP53,633 which is a basic non-steroidal anti-inflammatory agent Originated by Novartis.
20-O-Acetylingenol-3-angelate is a natural compound extracted from Euphorbia conspicua N. E. Br. It is used as molluscicidal agent, anti-cancer agent and cytost...
This bio-active molecular is a antibacterial agent with a pyrazolidinone structure.
Carzenide, a Sulfanilamide derivative, could be used as an intermediate to synthesize sorts of pharmaceuticals like carbonic anhydrase inhibitors.