Aconitine - CAS 302-27-2
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Aconitine
Catalog Number:
302-27-2
Synonyms:
Acetylbenzoylaconine
CAS Number:
302-27-2
Description:
Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.
Molecular Weight:
645.74
Molecular Formula:
C34H47NO11
COA:
Inquire
MSDS:
Inquire
Targets:
Others
Chemical Structure
CAS 302-27-2 Aconitine

Related Products


CAS 2076-91-7 TPT-260 2HCl

TPT-260 2HCl
(CAS: 2076-91-7)

TPT-260 is a thiophene thiourea derivative with molecule weight 260.00 in free base form. There is no formal name yet, we temporally call this molecule as TPT-2...

CAS 77-52-1 Ursolic acid

Ursolic acid
(CAS: 77-52-1)

Ursolic acid is a natural pentacyclic triterpenoid carboxylic acid. It exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

CAS 33231-14-0 DZ2002

DZ2002
(CAS: 33231-14-0)

DZ2002 is a potent and reversible S-Adenosyl-L-homocysteine Hydrolase(SAHH; AdoHcy Hydrolase) inhibitor with Ki of 17.9 nM.

CAS 633-65-8 Berberine HCl

Berberine HCl
(CAS: 633-65-8)

Berberine HCl is a quaternary ammonium salt from the group of isoquinoline alkaloids.

CAS 170787-99-2 Efaproxiral Sodium

Efaproxiral Sodium
(CAS: 170787-99-2)

Efaproxiral, a synthetic allosteric modifier of hemoglobinoxygen binding affinity, has been shown to bind reversibly to hemoglobin, stabilizing the deoxyhemoglobi...

CAS 135383-60-7 (S)-Dolaphenine hydrochloride

(S)-Dolaphenine hydrochloride
(CAS: 135383-60-7)

(S)-Dolaphenine hydrochloride is a useful componet for compound synthesis.

CAS 79416-27-6 5-Aminolevulinic acid methyl ester hydroChloride

5-Aminolevulinic acid methyl ester hydro
(CAS: 79416-27-6)

5-Aminolevulinic Acid Methyl Ester Hydrochlorideis the methyl ester of Aminolevulinic Acid. It shows much higher lipophilicity and highly efficient at inducing ...

CAS 849214-04-6 3'3'-cGAMP

3'3'-cGAMP
(CAS: 849214-04-6)

STING agonist

CAS 532-11-6 Anethole trithione

Anethole trithione
(CAS: 532-11-6)

Anethole trithione is a antitumor agent used in the treatment of dry mouth

CAS 549-18-8 Amitriptyline Hydrochloride

Amitriptyline Hydrochloride
(CAS: 549-18-8)

Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM,...

CAS 191089-59-5 K-7174

K-7174
(CAS: 191089-59-5)

K-7174 is a novel orally active, potent proteasome inhibitor. K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of cla...

CAS 21738-42-1 Oxamniquine

Oxamniquine
(CAS: 21738-42-1)

Oxamniquine, with schistosomicidal activity, is an antischistosomal drug used in the treatment of Schistosoma mansoni infection.

CAS 84692-91-1 Arglabin

Arglabin
(CAS: 84692-91-1)

Arglabin is a sesquiterpene gamma-lactone and is isolated from Artemisia glabella. It is anticancer natural compound.

GYKI-16638 HCl
(CAS: 307556-59-8)

GYKI-16638 is a novel antiarrhythmic agent, shows combined Class IB and Class III antiarrhythmic properties, resembling the electrophysiological manifestation s...

Cgp 21833
(CAS: 122378-49-8)

Cgp 21833 has a thiocarbonylamides structure and it is a potent antifilarial agent under laboratory research stage.

CAS 2591-17-5 D-Luciferin

D-Luciferin
(CAS: 2591-17-5)

D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-thr...

CAS 313553-47-8 INH1

INH1
(CAS: 313553-47-8)

INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.

CAS 55981-09-4 Nitazoxanide

Nitazoxanide
(CAS: 55981-09-4)

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)

CGP 55802A
(CAS: 152564-63-1)

CGP 55802A has been found to be a photoaffinity ligand that could be used to label NMDA receptor and have high selectivity to glutamate recognition site.

CAS 211110-63-3 Sobetirome

Sobetirome
(CAS: 211110-63-3)

Sobetirome selectively binds to and activates TRbeta over TRalpha and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol th...

Reference Reading


1. The toxicity of aconitine, emodin on ICC cell and the anagonist effect of the compatibility
PENG CHENG, WANG LAN, WANG YAN-HONG, LI YUN-XIA, PAN YUAN. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 2009, Vol. 34, No. 3&4, pp. 213-220
Aconitine (Fig 1) is the main active compound in total aconite alkaloid isolated from the root of aconitium plants, which has been widely used in China and other countries for a long time to therapeutically increase peripheral temperature, relieve rheumatic pain, treat neurological disorders, and improve cardiovascular function. Modern pharmacology studies have also shown that aconitine has effects of anti-inflammatory, analgesia and anesthesia, immune regulation, anti-tumor and so on. These data indicate that aconitine is an important medicine with multiple biological activities. However, aconitine was found to be harmful recently. Many studies have reported the damage of aconitine on macrophage, thymocyte, myocardial cells, sustentacular cells of testis, CHL cells, interstitial glands and so on. And the apoptosis of liver cells, renal tubular epithelial cells and cranial nerve cells induced by aconitine was also investigated. However, to our knowledge, no study of the aconitine effect on intestinal ICC cells was reported.
2. Study of Neurotoxic Effects and Underlying Mechanisms of Aconitine on Cerebral Cortex Neuron Cells
Cheng Peng, Tao Zheng, Fan Yang, Yun-Xia Li and Ding-Kun Zhang. Arch Pharm Res Vol 32, No 11, 1533-1543, 2009
Aconitine is a diterpene two-ester alkaloid derived from the tubers of aconitium plants, and has been used as traditional herbal medicine in China and Japan since ancient times to therapeutically increase peripheral temperature, relieve rheumatic pain, treat neurological disorders, and improve cardiovascular function (Sato et al., 1979; Hikino et al., 1980). Modern pharmacologic studies have shown that aconitine has effects of anti-inflammatory, analgesia and anesthesia (Ameri, 1998), immune regulation and anti-tumor.
3. Quantitative analysis of five toxic alkaloids in Aconitum pendulum using ultra-performance convergence chromatography (UPC2) coupled with mass spectrometry
Tang-Juan Zhao, Huan-Yang Qi, Juan Chen* and Yan-Ping Shi*. RSC Adv.,2015, 5,103869–103875
Aconitum pendulum Busch, known by the name Xueshang Yizhihao in Chinese, is a valuable Tibetan medicine among the Aconitum species due to its analgesic, anti-inflammatory and antibacterial activities, and its therapeutic effects of invigorating blood circulation and dispelling rheumatism. A. pendulum is widely distributed in the mountain grassy slopes and forest margins of the Qinghai–Tibet plateau, Yunnan province, Sichuan province, Gansu province and Shanxi province in China, at an altitude range of 2300–4500 m. In the previous phytochemical studies, a number of alkaloids, such as aconitine, deoxyaconitine, 3-acetylaconitine, hypaconitine, mesaconitine, 15a-hydroxyneoline, 8-O-acetyl-15a-hydroxyneoline, 14-benzoyl-8-O-methylaconine, neoline, benzoylaconine, polyschistine A, polyschistine D, N-deethyl-3-acetylaconitine, N-deethyldeoxyaconitine, secoaconitine, benzoyldeoxyaconitine, aconine, dehydrolucidusculline and dehydronapelline, have been isolated from A. pendulum. Among these alkaloids, the diester diterpenoid alkaloids (DDAs) have captured great attention for their high toxicity and wide range of bioactivities. For example, aconitine, an extremely toxic ingredient of A. pendulum, possessing a narrow therapeutic index, has striking pharmacological effects such as anti-inflammatory and antinociceptive properties. The poisonous dose of aconitine for humans is estimated to be 0.2 mg, and the lethal dose is 1–2 mg.