Aconitine - CAS 302-27-2
Not Intended for Therapeutic Use. For research use only.
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Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.
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CAS 302-27-2 Aconitine

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Reference Reading

1. The toxicity of aconitine, emodin on ICC cell and the anagonist effect of the compatibility
Aconitine (Fig 1) is the main active compound in total aconite alkaloid isolated from the root of aconitium plants, which has been widely used in China and other countries for a long time to therapeutically increase peripheral temperature, relieve rheumatic pain, treat neurological disorders, and improve cardiovascular function. Modern pharmacology studies have also shown that aconitine has effects of anti-inflammatory, analgesia and anesthesia, immune regulation, anti-tumor and so on. These data indicate that aconitine is an important medicine with multiple biological activities. However, aconitine was found to be harmful recently. Many studies have reported the damage of aconitine on macrophage, thymocyte, myocardial cells, sustentacular cells of testis, CHL cells, interstitial glands and so on. And the apoptosis of liver cells, renal tubular epithelial cells and cranial nerve cells induced by aconitine was also investigated. However, to our knowledge, no study of the aconitine effect on intestinal ICC cells was reported.
2. Study of Neurotoxic Effects and Underlying Mechanisms of Aconitine on Cerebral Cortex Neuron Cells
Cheng Peng, Tao Zheng, Fan Yang, Yun-Xia Li and Ding-Kun Zhang. Arch Pharm Res Vol 32, No 11, 1533-1543, 2009
Aconitine is a diterpene two-ester alkaloid derived from the tubers of aconitium plants, and has been used as traditional herbal medicine in China and Japan since ancient times to therapeutically increase peripheral temperature, relieve rheumatic pain, treat neurological disorders, and improve cardiovascular function (Sato et al., 1979; Hikino et al., 1980). Modern pharmacologic studies have shown that aconitine has effects of anti-inflammatory, analgesia and anesthesia (Ameri, 1998), immune regulation and anti-tumor.
3. Quantitative analysis of five toxic alkaloids in Aconitum pendulum using ultra-performance convergence chromatography (UPC2) coupled with mass spectrometry
Tang-Juan Zhao, Huan-Yang Qi, Juan Chen* and Yan-Ping Shi*. RSC Adv.,2015, 5,103869–103875
Aconitum pendulum Busch, known by the name Xueshang Yizhihao in Chinese, is a valuable Tibetan medicine among the Aconitum species due to its analgesic, anti-inflammatory and antibacterial activities, and its therapeutic effects of invigorating blood circulation and dispelling rheumatism. A. pendulum is widely distributed in the mountain grassy slopes and forest margins of the Qinghai–Tibet plateau, Yunnan province, Sichuan province, Gansu province and Shanxi province in China, at an altitude range of 2300–4500 m. In the previous phytochemical studies, a number of alkaloids, such as aconitine, deoxyaconitine, 3-acetylaconitine, hypaconitine, mesaconitine, 15a-hydroxyneoline, 8-O-acetyl-15a-hydroxyneoline, 14-benzoyl-8-O-methylaconine, neoline, benzoylaconine, polyschistine A, polyschistine D, N-deethyl-3-acetylaconitine, N-deethyldeoxyaconitine, secoaconitine, benzoyldeoxyaconitine, aconine, dehydrolucidusculline and dehydronapelline, have been isolated from A. pendulum. Among these alkaloids, the diester diterpenoid alkaloids (DDAs) have captured great attention for their high toxicity and wide range of bioactivities. For example, aconitine, an extremely toxic ingredient of A. pendulum, possessing a narrow therapeutic index, has striking pharmacological effects such as anti-inflammatory and antinociceptive properties. The poisonous dose of aconitine for humans is estimated to be 0.2 mg, and the lethal dose is 1–2 mg.