Aconine - CAS 509-20-6
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Aconine
Catalog Number:
509-20-6
Synonyms:
Jesaconine; 11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine;
CAS Number:
509-20-6
Description:
Aconine is extracted form the roots of Aconitum kusnezoffii Reichb, a derivative of Aconitine.
Molecular Weight:
499.59
Molecular Formula:
C25H41NO9
Quantity:
Milligrams-Grams
Quality Standard:
Enterprise Standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CCN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6O)(C(C5O)OC)O)O)OC)OC)O)COC
InChI:
1S/C25H41NO9/c1-6-26-9-22(10-32-2)12(27)7-13(33-3)24-11-8-23(30)19(28)14(11)25(31,20(29)21(23)35-5)15(18(24)26)16(34-4)17(22)24/h11-21,27-31H,6-10H2,1-5H3/t11-,12-,13+,14-,15+,16+,17-,18?,19-,20+,21+,22+,23-,24+,25-/m1/s1
InChIKey:
SQMGCPHFHQGPIF-JIOYIOPFSA-N
Targets:
Others
Chemical Structure
CAS 509-20-6 Aconine

Related Products


Cp-76593
(CAS: 115898-30-1)

This active molecular is a bio-active chemical and detailed information has not been published yet.

CAS 299-28-5 Gluconate Calcium

Gluconate Calcium
(CAS: 299-28-5)

Gluconate Calcium is an calcium supplement used in crop pesticide formulations and also in the treatment of too little calcium in the blood.

CAS 80418-24-2 Notoginsenoside R1

Notoginsenoside R1
(CAS: 80418-24-2)

Notoginsenoside R1 is extracted from the roots of Panax notoginseng (Burk.)F.H.Chen. It has some neuronal protective, antihypertensive effects and exhibits anti...

JNJ-42165279 hydrochloride
(CAS: 1346528-52-6)

CAS 478-08-0 Lucidin

Lucidin
(CAS: 478-08-0)

Lucidin is a natural component of Rubia tinctorum L.

CAS 28598-08-5 Cinoctramide

Cinoctramide
(CAS: 28598-08-5)

Cinoctramide is an intermediate of pharmaceutical synthesis.

CAS 1195-16-0 DL-N-Acetylhomocysteine thiolactone

DL-N-Acetylhomocysteine thiolactone
(CAS: 1195-16-0)

DL-N-Acetylhomocysteine thiolactone, an amino acid cysteine derivative, could be used against some liver diseases.

CAS 58-46-8 Tetrabenazine

Tetrabenazine
(CAS: 58-46-8)

Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder. It is a monoamine-depleting and a dopamine-receptor-blocking drug and is...

CAS 79416-27-6 5-Aminolevulinic acid methyl ester hydroChloride

5-Aminolevulinic acid methyl ester hydro
(CAS: 79416-27-6)

5-Aminolevulinic Acid Methyl Ester Hydrochlorideis the methyl ester of Aminolevulinic Acid. It shows much higher lipophilicity and highly efficient at inducing ...

CAS 456-59-7 Cyclandelate

Cyclandelate
(CAS: 456-59-7)

Cyclandelate is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.

CAS 69363-14-0 Schisanhenol

Schisanhenol
(CAS: 69363-14-0)

Schisanhenol, isolated from Schisandra rubriflora, has antioxidative effect on human LDL oxidation. The mechanism of Schisanhenol against LDL oxidation may be t...

CAS 19666-76-3 Panaxadiol

Panaxadiol
(CAS: 19666-76-3)

Panaxadiol, a triterpenoid compound extracted from roots of Panax ginseng C, a novel antitumor agent that regulates of cell cycle transition and induces apoptot...

CAS 288-32-4 Imidazole

Imidazole
(CAS: 288-32-4)

Imidazole, a highly polar compound, has been used extensively as a corrosion inhibitor and a buffer in the pH range of 6.2-7.8.

GSK-1268992
(CAS: 1414375-49-7)

GSK-1268992 is one of a metabolite of Pazopanib which is a selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits an...

CAS 51037-30-0 Acipimox

Acipimox
(CAS: 51037-30-0)

Acipimox (trade name Olbetam in Europe) is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, ...

CAS 102767-28-2 Levetiracetam

Levetiracetam
(CAS: 102767-28-2)

Levetiracetam is an anticonvulsant medication used to treat epilepsy.

CAS 112809-51-5 Letrozole

Letrozole
(CAS: 112809-51-5)

Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM.

KLS-13019
(CAS: 1801243-39-9)

KLS-13019, an azetidine derivative, could be a neuroprotective agent and has been found to exbihit much more effective than cannabidiol.

CAS 147591-46-6 ID-8

ID-8
(CAS: 147591-46-6)

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.

NS-2214
(CAS: 171655-92-8)

NS-2214, an azabicyclo compound, has been found to be a dopamine uptake inhibitor that was once studied in the treatment of Parkinson's disease.

Reference Reading


1.Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression.
Zeng XZ1,2, He LG1, Wang S3, Wang K1, Zhang YY1, Tao L1, Li XJ1, Liu SW1. Acta Pharmacol Sin. 2016 Feb;37(2):255-63. doi: 10.1038/aps.2015.85. Epub 2015 Nov 23.
AIM: Aconiti Lateralis Radix Preparata is a traditional Chinese medicine used to treat chronic arthritis and is highly effective against rheumatoid arthritis. However, the effects of aconine, a derivative of aconitum alkaloids, on osteoclasts, which can absorb bone, remain unknown. Here, we investigated the effects of aconine on osteoclast differentiation and bone resorption in vitro.
2.Ring A conformation of aconine and pseudaconine in CDCl3.
Deng HY, Chen QH, Wang FP. Nat Prod Commun. 2014 Jun;9(6):785-6.
On the basis of intensive interpretation of the 1H NMR spectroscopic data, the ring A conformation of aconine (1) was speculated as twist boat in CDCl3, and as chair or twist boat in acetone-d6 and pyridine-d5. The ring A of pseudaconine (2) adopts the chair conformation in CDCl3, acetone-d6, and pyridine-ds. Accordingly, the boat conformation of ring A in these two diterpenoid alkaloids in CDCl3 reported in the literature [1] should be revised. The difference in 13C NMR data for the same compound (1 or 2) in two different solvents (CDCl3, pyridine-d5) can be attributed to solvent effects.
3.Biological activities and pharmacokinetics of aconitine, benzoylaconine, and aconine after oral administration in rats.
Zhang H1,2, Sun S1, Zhang W1, Xie X3, Zhu Z2, Chai Y2, Zhang G1. Drug Test Anal. 2015 Sep 11. doi: 10.1002/dta.1858. [Epub ahead of print]
Aconitine (AC), benzoylaconine (BAC), and aconine (ACN) are three representative alkaloids in Aconitum tubers. Knowing that the drug disposal process in vivo is closely related to the toxicity and efficacy of a drug, it is important to classify the disposal properties of these alkaloids. In this study, the pharmacokinetics of the three alkaloids was investigated. The results showed that the three alkaloids could be quickly absorbed, especially BAC, whose Tmax was 0.31 ± 0.17 h. Their Cmax was 10.99, 3.99, and 4.29 ng·mL-1 respectively, indicating that AC had better absorption than BAC and ACN. Subsequently, we further investigated their absorption mechanism using the Caco-2 cell monolayer model in vitro. The results showed that they were poorly absorbed, and the absorption of AC and BAC was inhibited by P-gp, while the absorption of ACN was in a form of passive diffusion. The t1/2 of AC, BAC and ACN was 1.41, 9.49, and 3.32 h, respectively, indicating that the metabolic or excretion rate of AC was quicker than that of BAC and ACN.