Acetylpromazine - CAS 61-00-7
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Acetylpromazine
Catalog Number:
61-00-7
Synonyms:
10-[3-[Dimethylamino] propyl] phenothiazin-2-yl methyl ketone;Ethanone, 1-10-3-(dimethylamino)propyl-10H-phenothiazin-2-yl-;1-[10-(3-dimethylaminopropyl)phenothiazin-2-yl]ethanone;Plegicil;Vetranquil;1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethano
CAS Number:
61-00-7
Description:
Acetylpromazine is a phenothiazine derivative. It has depressant effect on the central nervous system and is used in the treatment of psychoses. It is now almost exclusively used on animals as a sedative and antiemetic. It is used primarily as a chemical restraint in hyperactive or fractious animals. It acts as a dopamine receptor antagonist in the central nervous system, thus causing sedation, muscular relaxation and a reduction in spontaneous activity. It acts as an antagonist on different postsysnaptic receptors -on dopaminergic-receptors, on serotonergic-receptors, on histaminergic-receptors and so on. It has been listed.
Molecular Weight:
326.46
Molecular Formula:
C19H22N2OS
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C
InChI:
InChI=1S/C19H22N2OS/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19/h4-5,7-10,13H,6,11-12H2,1-3H3
InChIKey:
NOSIYYJFMPDDSA-UHFFFAOYSA-N
Current Developer:
Acetylpromazine has been listed.
Chemical Structure
CAS 61-00-7 Acetylpromazine

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Reference Reading


1.Clinical effects of midazolam or lidocaine co-induction with a propofol target-controlled infusion (TCI) in dogs.
Minghella E1, Auckburally A1, Pawson P1, Scott ME2, Flaherty D1. Vet Anaesth Analg. 2016 Feb 2. doi: 10.1111/vaa.12336. [Epub ahead of print]
OBJECTIVE: To evaluate the propofol requirement, cardiovascular and respiratory variables using midazolam or lidocaine with a propofol target-controlled infusion (PTCI) for induction of anaesthesia in healthy dogs.
2.Inhaled Anesthetics Exert Different Protective Properties in a Mouse Model of Ventilator-Induced Lung Injury.
Strosing KM1, Faller S, Gyllenram V, Engelstaedter H, Buerkle H, Spassov S, Hoetzel A. Anesth Analg. 2016 Mar 28. [Epub ahead of print]
BACKGROUND: Mechanical ventilation is an important perioperative tool in anesthesia and a lifesaving treatment for respiratory failure, but it can lead to ventilator-associated lung injury. Inhaled anesthetics have demonstrated protective properties in various models of organ damage. We compared the lung-protective potential of inhaled sevoflurane, isoflurane, and desflurane in a mouse model of ventilator-induced lung injury (VILI).
3.Intraperitoneal bupivacaine with or without incisional bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy.
Kalchofner Guerrero KS1, Campagna I2, Bruhl-Day R1, Hegamin-Younger C3, Guerrero TG1. Vet Anaesth Analg. 2016 Feb 12. doi: 10.1111/vaa.12348. [Epub ahead of print]
OBJECTIVE: Intraperitoneal (IP) bupivacaine provides postoperative analgesia in dogs undergoing ovariohysterectomy (OHE) alone or in combination with incisional (INC) bupivacaine. This study investigated whether the combination of INC and IP bupivacaine is superior to IP bupivacaine alone.
4.The effects of acupuncture point Pericardium 6 on hydromorphone-induced nausea and vomiting in healthy dogs.
Scallan EM1, Simon BT1. Vet Anaesth Analg. 2016 Feb 18. doi: 10.1111/vaa.12347. [Epub ahead of print]
OBJECTIVE: To evaluate the effect of needling at acupuncture point Pericardium 6 on hydromorphone-induced nausea and vomiting.