Acetaminophen - CAS 103-90-2
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Acetaminophen
Catalog Number:
103-90-2
Synonyms:
Paracetamol; Tylenol; 4'-Hydroxyacetanilide; 4-Acetamidophenol; APAP
CAS Number:
103-90-2
Description:
A selective COX-2 inhibitor
Molecular Weight:
151.16
Molecular Formula:
C8H9NO2
Quantity:
Grams-Kilos
Quality Standard:
In-house
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(=O)NC1=CC=C(C=C1)O
InChI:
1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
InChIKey:
RZVAJINKPMORJF-UHFFFAOYSA-N
Targets:
Cox-2 | COX
Chemical Structure
CAS 103-90-2 Acetaminophen

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Reference Reading


1.Evaluation of Hepatoprotective Activity of Adansonia digitata Extract on Acetaminophen-Induced Hepatotoxicity in Rats.
Hanafy A1, Aldawsari HM2, Badr JM3, Ibrahim AK4, Abdel-Hady Sel-S2. Evid Based Complement Alternat Med. 2016;2016:4579149. doi: 10.1155/2016/4579149. Epub 2016 Mar 16.
The methanol extract of the fruit pulp of Adansonia digitata L. (Malvaceae) was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress. In addition, hepatospecific serum markers will be disturbed. Treatment of the rats with the methanol extract of the fruit pulp of Adansonia digitata L. prior to administration of acetaminophen significantly reduced the disturbance in liver function. Liver functions were measured by assessment of total protein, total bilirubin, ALP, ALT, and AST. Oxidative stress parameter and antioxidant markers were also evaluated. Moreover, histopathological evaluation was performed in order to assess liver case regarding inflammatory infiltration or necrosis. Animals were observed for any symptoms of toxicity after administration of extract of the fruit pulp of Adansonia digitata L.
2.Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better.
Natoli S1,2, Lazzari M3,4, Carpenedo R4, Palombo E4, Silvi MB3,4, Mammucari M5, Dauri M3,4. Adv Ther. 2016 May 3. [Epub ahead of print]
INTRODUCTION: Oxycodone is one of the most commonly used opioid analgesics in the clinical management of pain. The present retrospective analysis aimed to determine the dose of oxycodone that could achieve effective control of moderate pain when combined with a fixed dose of acetaminophen, and the time required to reach a clinically relevant reduction in intensity of pain.
3.Removal of Acetaminophen-Protein Adducts by Autophagy Protects Against Acetaminophen-Induced Liver Injury in Mice.
Ni HM1, McGill MR1, Chao X1, Du K1, Williams JA1, Xie Y1, Jaeschke H1, Ding WX2. J Hepatol. 2016 May 2. pii: S0168-8278(16)30169-6. doi: 10.1016/j.jhep.2016.04.025. [Epub ahead of print]
BACKGROUND & AIMS: Acetaminophen (APAP)-induced liver injury is the most frequent cause of acute liver failure in the US and many other countries. Metabolism of APAP results in formation of APAP protein adducts (APAP-AD) in hepatocytes and triggers mitochondrial dysfunction and necrosis. However, the mechanisms for how APAP-AD are removed from hepatocytes remain unknown.
4.Reaction kinetics and oxidation product formation in the degradation of acetaminophen by ferrate (VI).
Wang H1, Liu Y2, Jiang JQ3. Chemosphere. 2016 May 4;155:583-590. doi: 10.1016/j.chemosphere.2016.04.088. [Epub ahead of print]
This paper investigates the degradation of acetaminophen (AAP) in aqueous solutions by ferrate (VI), aiming to propose the kinetics, pathways and the oxidation products' formation in the AAP degradation. A series of jar tests were undertaken over ferrate (VI) dosages (molar ratios of ferrate (VI):AAP, 5:1 to 25:1) and pH values (4-11). The effects of co-existing ions (0.2-5 mM) and humic acid (10-50 mg l-1) on the AAP removal were investigated. Ferrate (VI) can remove 99.6% AAP (from 1000 μg l-1) in 60 min under study conditions when majority of the AAP reduction occurred in the first 5 min. The treatment performance depended on the ferrate(VI) dosage, pH and the type and strength of co-existing ions and humic acid. Raising ferrate (VI) dosage with optimal pH 7 improved the AAP degradation. In the presence of humic acid, the AAP degradation by ferrate (VI) was promoted in a short period (<30 min) but then inhibited with increasing in humic acid contents.