Acelarin - CAS 840506-29-8
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Acelarin
Catalog Number:
840506-29-8
Synonyms:
NUC-1031; GTPL7389; SCHEMBL17171316; Benzyl (2S)-2-[({[(2R,3S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy}(phenoxy)phosphoryl)amino]propanoate
CAS Number:
840506-29-8
Description:
Acelarin is a DNA synthesis inhibitor with EC50 of 0.2 nM. Acelarin is a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine. It is converted into the active metabolites dFdCDP and dFdCTP. dFdCDP can inhibit ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA replication; dFdCTP can be incorporated into DNA, resulting in premature termination of DNA replication and eventually induction of apoptosis. Phase III clinical trials for te treatment of Pancreatic cancer are on-going.
Molecular Weight:
580.48
Molecular Formula:
C25H27F2N4O8P
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(C(=O)OCC1=CC=CC=C1)NP(=O)(OCC2C(C(C(O2)N3C=CC(=NC3=O)N)(F)F)O)OC4=CC=CC=C4
InChI:
InChI=1S/C25H27F2N4O8P/c1-16(22(33)36-14-17-8-4-2-5-9-17)30-40(35,39-18-10-6-3-7-11-18)37-15-19-21(32)25(26,27)23(38-19)31-13-12-20(28)29-24(31)34/h2-13,16,19,21,23,32H,14-15H2,1H3,(H,30,35)(H2,28,29,34)/t16-,19+,21-,23+,40?/m0/s1
InChIKey:
NHTKGYOMICWFQZ-BSMFTPRPSA-N
Targets:
DNA/RNA Synthesis
Current Developer:
NuCana

Related DNA/RNA Synthesis Products


CP 115953
(CAS: 136440-70-5)

CP 115953 is a Type II DNA topoisomerase inhibitor originated by Pfizer. CP 115953 inhibits topoisomerase II activity via an interaction with the enzyme and not...

CP-74667 mesylate
(CAS: 138808-71-6)

CP-74667 is a Type II DNA topoisomerase inhibitor originated by Pfizer. No development was reported for Bacterial infections in USA.

CAS 152247-02-4 CP 80080

CP 80080
(CAS: 152247-02-4)

CP 80080, a quinolinecarboxylic acid derivative, has been found to influencing DNA cleavage slightly and could probably be used in th anticancer studies.

Acelarin
(CAS: 840506-29-8)

Acelarin is a DNA synthesis inhibitor with EC50 of 0.2 nM. Acelarin is a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine. It is converted ...

CAS 127759-89-1 Lobucavir

Lobucavir
(CAS: 127759-89-1)

Lobucavir is a RNA-directed DNA polymerase inhibitor originated by Bristol-Myers Squibb as a nucleoside analog. Treatment for Cytomegalovirus infections, Hepati...

Tinostamustine Hydrochloride
(CAS: 1793059-58-1)

The hydrochloride salt form of Tinostamustine, a benzimidazol derivative, has been found to be a HDAC inhibitor and could probably be effective against sorts of...

CAS 1247847-78-4 Simmitecan Hydrochloride

Simmitecan Hydrochloride
(CAS: 1247847-78-4)

This active molecular is a topoisomerase I inhibitor originated by ShangHai HaiHe Pharmaceutical. Simmitecan is also a promising water-soluble prodrug of chimmi...

GSK299423
(CAS: 1352149-24-6)

GSK299423 is an antibiotic agent and it seems potentially effective in treating patients infected with bacteria expressing the New Delhi metallo-beta-lactamase....

CAS 1138549-36-6 CX-5461

CX-5461
(CAS: 1138549-36-6)

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 2...

Doravirine
(CAS: 1338225-97-0)

Doravirine is a non-nucleoside reverse transcriptase inhibitor under development of Merck & Co. IC 50 value is 12 nM against the wild type, 21nM against K103N, ...

TH588 hydrochloride
(CAS: 1640282-30-9)

TH588 hydrochloride, with potent anti-cancer property, is a novel inhibitor that highly selectively targets MTH1 protein (IC50= 5 nM) which is required for canc...

CAS 841301-32-4 Amenamevir

Amenamevir
(CAS: 841301-32-4)

Amenamevir is a DNA helicase-primase inhibitors. It has anti-HSV activity against herpes simplex keratitis. In Mar 2016, Mahuro completed a phase III trial in H...

CAS 127-07-1 Hydroxyurea

Hydroxyurea
(CAS: 127-07-1)

Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

TH287
(CAS: 1609960-30-6)

TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.

CAS 81424-67-1 Caracemide

Caracemide
(CAS: 81424-67-1)

Caracemide is an agent derived from acetohydroxamic acid. It has potential antineoplastic activity. Caracemide can inhibit ribonuclease reductase, resulting in ...

CAS 84472-85-5 Navuridine

Navuridine
(CAS: 84472-85-5)

Navuridine is a RNA-directed DNA polymerase inhibitor under the development of Bayer HealthCare Pharmaceuticals. But research for the teatment of HIV infections...

CAS 14698-29-4 Oxolinic acid

Oxolinic acid
(CAS: 14698-29-4)

Oxolinic acid, a potent inhibitor of DNA gyrase and DNA synthesis, can examined Gyrase-chromosome interactions.

LMI070
(CAS: 1562338-42-4)

LMI070, also called as NVS-SM1, is a selective, high plasma exposure and orally active modulator of SMN2 splicing which demonstrates robust activity across dise...

CAS 129716-45-6 MS-073

MS-073
(CAS: 129716-45-6)

MS-073 is a Type II DNA topoisomerase inhibitor under the development of Nihon Schering. MS-073 can overcome MDR in vitro and in vivo compare to verapamil. MS-0...

CAS 87434-82-0 Dezaguanine Mesilate

Dezaguanine Mesilate
(CAS: 87434-82-0)

Dezaguanine is a new antipurine antimetabolite. Dezaguanine is a DNA synthesis inhibitor. It has significant activity against transplantable rodent solid tumors...