Aceclofenac - CAS 89796-99-6
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Aceclofenac
Catalog Number:
89796-99-6
Synonyms:
Preservex
CAS Number:
89796-99-6
Description:
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. It works by blocking the action of a substance in the body called cyclo-oxygenase.
Molecular Weight:
354.18
Molecular Formula:
C16H13Cl2NO4
COA:
Inquire
MSDS:
Inquire
Targets:
COX
Chemical Structure
CAS 89796-99-6 Aceclofenac

Related COX Products


CAS 169590-42-5 Celecoxib

Celecoxib
(CAS: 169590-42-5)

A highly selective COX-2 inhibitor

BMS-347070
(CAS: 197438-73-6)

BMS-347070 is a COX-2 inhibitor, initially developed for the treatment for Colorectal cancer.

CAS 68767-14-6 Loxoprofen

Loxoprofen
(CAS: 68767-14-6)

Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is a n...

CAS 78281-72-8 Nepafenac

Nepafenac
(CAS: 78281-72-8)

An inhibitor of COX-1 and COX-2

CAS 15687-27-1 Ibuprofen (Dolgesic)

Ibuprofen (Dolgesic)
(CAS: 15687-27-1)

An inhibitor of COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively

CAS 13710-19-5 Tolfenamic Acid

Tolfenamic Acid
(CAS: 13710-19-5)

A COX-2 inhibitor with IC50 of 0.2 μM

CAS 123653-11-2 NS 398

NS 398
(CAS: 123653-11-2)

A selective COX-2 inhibitor

CAS 1226895-20-0 ATB 346

ATB 346
(CAS: 1226895-20-0)

CAS 141505-32-0 Ibuprofen lysinate

Ibuprofen lysinate
(CAS: 141505-32-0)

Dexibuprofen is a Cyclooxygenase inhibitor originated by Gebro Pharma GmbH. It is a non-steroidal anti-inflammatory drug as the active dextrorotatory enantiomer...

CAS 53-86-1 Indomethacin

Indomethacin
(CAS: 53-86-1)

A nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively

PD 127443
(CAS: 121502-05-4)

This active molecular is a Leukotriene B4 antagonist. PD- 127443 is also a 5-lipoxygenase and cyclooxygenase inhibitor and it has been reported to have antiinfl...

CAS 71125-38-7 Meloxicam

Meloxicam
(CAS: 71125-38-7)

Meloxicam (Mobic) is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects.

CAS 78213-16-8 Diclofenac Diethylamine

Diclofenac Diethylamine
(CAS: 78213-16-8)

Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

CAS 188817-13-2 SC-560

SC-560
(CAS: 188817-13-2)

SC-560 is an orally active and highly selective cyclooxygenase-1 (COX-1) inhibitor with IC50= 0.009 μM for COX-1, and 6.3 μM for COX-2. SC-560 also significantl...

CAS 62-44-2 Phenacetin

Phenacetin
(CAS: 62-44-2)

Phenacetin is a non-opioid analgesic without anti-inflammatory properties. It is a pain-relieving and fever-reducing drug and was withdrawn from the Canadian ma...

CAS 19210-12-9 Harpagoside

Harpagoside
(CAS: 19210-12-9)

Harpagoside, isolated from the Harpagophytum procumbens (Devil's Claw) root or Crophularia ningpoensis Hemsl (Figwort), inhibited lipopolysaccharide-induced mRN...

CAS 74103-06-3 Ketorolac

Ketorolac
(CAS: 74103-06-3)

Ketorolac, a non-selective COX inhibitor, is a non-steroidal anti-inflammatory drug. It shows inhibition of eicosanoid formation in HEL cells (COX-1) and LPS-st...

CAS 50-78-2 Aspirin

Aspirin
(CAS: 50-78-2)

A salicylate and irreversible COX1 and COX2 inhibitor

CAS 163133-43-5 4-(NITROOXY)BUTYL (2S)-2-(6-METHOXY-2-NAPHTHYL)PROPANOATE

4-(NITROOXY)BUTYL (2S)-2-(6-METHOXY-2-NA
(CAS: 163133-43-5)

Naproxcinod, a nitro compound, has been found to be a nitric oxide donor as well as a cyclooxygenase inhibitor that was once studied aginast duchenne muscular d...

CAS 36740-73-5 Flumizole

Flumizole
(CAS: 36740-73-5)

Flumizole is a non-steroidal anti-inflammatory drug (NSAID) that acts via inhibition of the enzyme cyclooxygenase (COX).

Reference Reading


1.Glucocorticoids and chronotherapy in rheumatoid arthritis.
Cutolo M1. RMD Open. 2016 Mar 18;2(1):e000203. doi: 10.1136/rmdopen-2015-000203. eCollection 2016.
It is evident that the morning symptoms of rheumatoid arthritis (RA) are linked to the circadian abnormal increase in night inflammation, favoured by inadequate cortisol secretion under conditions of active disease. Therefore, exogenous glucocorticoid treatment is recommended in RA at low doses since it may partially act like a 'replacement therapy'. The prevention/treatment of the night upregulation of the immune/inflammatory reaction (and related flare of cytokine synthesis) has been shown to be more effective when exogenous glucocorticoid administration is obtained with a night-time-release formulation. Large-scale trials documented that modified-release prednisone has greater efficacy then morning prednisone for long-term low-dose glucocorticoid treatment in patients with RA, showing at least a more significant reduction in morning joint stiffness. Interestingly, despite a considerably higher cost than conventional prednisone, chronotherapy with night-time-release prednisone was recognised as a cost-effective option for patients with RA not on glucocorticoids who are eligible for therapy with biological disease-modifying antirheumatic drugs (DMARDs).
2.Development and validation of an LC-ESI-MS/MS method for the simultaneous quantification of naproxen and sumatriptan in human plasma: application to a pharmacokinetic study.
Brêtas JM1, César IC2, Brêtas CM1, Teixeira LS3, Bellorio KB3, Mundim IM3, Pianetti GA1. Anal Bioanal Chem. 2016 Mar 28. [Epub ahead of print]
A sensitive and fast liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method was developed and validated for the simultaneous quantification of naproxen and sumatriptan in human plasma. A simple liquid-liquid extraction procedure, with a mixture of ethyl acetate, methyl tert-butyl ether, and dichloromethane (4:3:3, v/v), was used for the cleanup of plasma. Naratriptan and aceclofenac were employed as internal standards. The analyses were carried out using an ACE C18 column (50 × 4.6 mm i.d.; particle size 5 μm) and a mobile phase consisting of 2 mM aqueous ammonium acetate with 0.025 % formic acid and methanol (38:62, v/v). A triple-quadrupole mass spectrometer equipped with an electrospray source in the positive mode was set up in the selective reaction monitoring mode to detect the ion transitions m/z 231.67 → m/z 185.07, m/z 296.70 → m/z 157.30, m/z 354.80 → m/z 215.00, and m/z 336.80 → m/z 97.94 for naproxen, sumatriptan, aceclofenac, and naratriptan, respectively.
3.Development and evaluation of decorated aceclofenac nanocrystals.
Park JJ1, Meghani N1, Choi JS2, Lee BJ3. Colloids Surf B Biointerfaces. 2016 Mar 10;143:206-212. doi: 10.1016/j.colsurfb.2016.03.022. [Epub ahead of print]
This study was aimed at achieving enhanced solubility of aceclofenac (ACF) in nanocrystaline forms (ACF-NC) and evaluating the effects of ACF-NC on cell viability. Decorated ACF-NC were prepared by nano-precipitation with stabilizers. Three kinds of stabilizers were investigated: Tween 80, Poloxamer 407, and PEG 6000. The crystal structure and morphology of ACF-NC were characterized by field emission scanning electron microscopy (FE-SEM) and differential scanning calorimetry (DSC). The solubility of ACF-NC and ACF (pure) was evaluated in different media (pH 1.2 and pH 6.8 buffers and distilled water [DW]). A drug release study was performed in PBS for 24h. Cell viability was evaluated for 24h using a human colon cancer cell-line (HCT-116) and a human breast cancer cell-line (MCF-7). Decorated ACF-NC with a mean size of 725nm were successfully prepared. The solubility of the decorated ACF-NC were 4-7 times higher than that of ACF in DW and pH 6.
4.Novel elastic membrane vesicles (EMVs) and ethosomes-mediated effective topical delivery of aceclofenac: a new therapeutic approach for pain and inflammation.
Sharma G1, Goyal H1, Thakur K1, Raza K2, Katare OP1. Drug Deliv. 2016 Mar 10:1-11. [Epub ahead of print]
CONTEXT: Aceclofenac (ACE) is a systematically designed drug, developed to circumvent the concerns associated with diclofenac. But ACE is also associated with non-steroidal anti-inflammatory drug (NSAIDs)-tagged side effects, although of decreased amplitude.