|Synonyms||AICA riboside; AICAr ; AICA-riboside; Arasine; Protara; AIC-Riboside; Z-Riboside; AICA riboside; AICA; AICAR.|
|Description||Acadesine is a 5-aminoimidazole-4-carboxamide (AICA) riboside, a purine nucleoside analog, and a nucleotide biosynthesis precursor with B cell pro-apoptotic activity. Following cellular uptake, acadesine is phosphorylated to AICA ribotide (ZMP), which mimics 5'-adenosine monophosphate (AMP). Acadesine-induced apoptosis also appears to require cytochrome c release from mitochondria and caspase activation and is p53-independent. However, the exact mechanism of acadesine-induced apoptosis is unknown.|
|Current Developer||PeriCor Therapeutics; Protherics PLC; Schering-Plough.|
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