Acadesine - CAS 2627-69-2
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Acadesine
Catalog Number:
2627-69-2
Synonyms:
AICA riboside; AICAr ; AICA-riboside; Arasine; Protara; AIC-Riboside; Z-Riboside; AICA riboside; AICA; AICAR.
CAS Number:
2627-69-2
Description:
Acadesine is a 5-aminoimidazole-4-carboxamide (AICA) riboside, a purine nucleoside analog, and a nucleotide biosynthesis precursor with B cell pro-apoptotic activity. Following cellular uptake, acadesine is phosphorylated to AICA ribotide (ZMP), which mimics 5'-adenosine monophosphate (AMP). Acadesine-induced apoptosis also appears to require cytochrome c release from mitochondria and caspase activation and is p53-independent. However, the exact mechanism of acadesine-induced apoptosis is unknown.
COA:
Inquire
MSDS:
Inquire
Targets:
AMPK
Current Developer:
PeriCor Therapeutics; Protherics PLC; Schering-Plough.
Chemical Structure
CAS 2627-69-2 Acadesine

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