AC710 - CAS 1351522-04-7
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
AC710
Catalog Number:
1351522-04-7
Synonyms:
AC 710; AC-710
CAS Number:
1351522-04-7
Description:
AC710 is a potent, selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. AC710 is now a preclinical development candidate.
Molecular Weight:
562.7
Molecular Formula:
C31H42N6O4
COA:
Inquire
MSDS:
Inquire
Targets:
PDGFR
Chemical Structure
CAS 1351522-04-7 AC710

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Reference Reading


1.Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases.
Liu G1, Campbell BT1, Holladay MW1, Ford Pulido JM1, Hua H1, Gitnick D1, Gardner MF1, James J1, Breider MA1, Brigham D1, Belli B1, Armstrong RC1, Treiber DK1. ACS Med Chem Lett. 2012 Sep 24;3(12):997-1002. doi: 10.1021/ml300214g. eCollection 2012.
A series of potent, selective platelet-derived growth factor receptor-family kinase inhibitors was optimized starting from a globally selective lead molecule 4 through structural modifications aimed at improving the physiochemical and pharmacokinetic properties, as exemplified by 18b. Further clearance reduction via per-methylation of the α-carbons of a solubilizing piperidine nitrogen resulted in advanced leads 22a and 22b. Results from a mouse tumor xenograft, a collagen-induced arthritis model, and a 7 day rat in vivo tolerability study culminated in the selection of compound 22b (AC710) as a preclinical development candidate.