ABTL-0812 - CAS 57818-44-7
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
ABTL-0812
Catalog Number:
57818-44-7
Synonyms:
ABTL0812;(9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate
CAS Number:
57818-44-7
Description:
ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015.
Molecular Weight:
294.93
Molecular Formula:
C18H31O3
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CCCCC/C=C\C/C=C\CCCCCCC(O)C([O-])=O
InChI:
InChI=1/C18H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h6-7,9-10,17,19H,2-5,8,11-16H2,1H3,(H,20,21)/b7-6-,10-9-/f/h20H
InChIKey:
AFDSETGKYZMEEA-HZJYTTRNSA-N
Targets:
mTOR
Current Developer:
ABTL-0812 was developed by Ability Pharmaceuticals and is in phase I/II clinical trials. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015.

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