ABT 751 - CAS 141430-65-1
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
ABT 751
Catalog Number:
141430-65-1
Synonyms:
N-[2-(4-hydroxyanilino)pyridin-3-yl]-4-methoxybenzenesulfonamide; E 7010; E-7010; E7010; N-(2-((4-hydroxyphenyl)amino)-3-pyridinyl)-4-methoxybenzenesulfonamide; ABT-751; 141430-65-1; ABT 751; E-7010; ABT751; UNII-WDT5V5OB9F; E 7010; WDT5V5OB9F; CHEMBL20684
CAS Number:
141430-65-1
Description:
ABT 751, also called E7010, is a a novel bioavailable tubulin-binding and antimitotic agent (in neuroblastoma: IC50= 0.6–2.6 μM; in non-neuroblastoma cell lines: IC50=0.7–4.6 μM)
Molecular Weight:
371.41
Molecular Formula:
C18H17N3O4S
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O
InChI:
1S/C18H17N3O4S/c1-25-15-8-10-16(11-9-15)26(23,24)21-17-3-2-12-19-18(17)20-13-4-6-14(22)7-5-13/h2-12,21-22H,1H3,(H,19,20)
InChIKey:
URCVCIZFVQDVPM-UHFFFAOYSA-N
Targets:
Microtubule/Tubulin
Chemical Structure
CAS 141430-65-1 ABT 751

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Reference Reading


1.Design, synthesis and antiproliferative activity of the new conjugates of E7010 and resveratrol as tubulin polymerization inhibitors.
Kamal A1, Ashraf M, Basha ST, Ali Hussaini SM, Singh S, Vishnuvardhan MV, Kiran B, Sridhar B. Org Biomol Chem. 2016 Jan 28;14(4):1382-94. doi: 10.1039/c5ob02022k. Epub 2015 Dec 16.
A new class of (E)-N-phenyl-3-styrylpyridin-2-amine conjugates were designed and synthesized on the basis of E7010 and resveratrol scaffolds. These conjugates were evaluated for their antiproliferative activity in four human cancer cell lines with GI50 values ranging from 2.1 μM to 20 μM. Two of the conjugates RSV-1 and RSV-11 were found to possess 13-fold higher GI50 values than resveratrol and 1 to 2 fold higher GI50 values than E7010 against the human cervical HepG2 cancer line. They displayed high potency and selectivity in a panel of NCI 60 human cancer cell lines. Based on the GI50 values against the panel of 60 NCI cancer cell lines and dock scores from the molecular modelling studies, we selected RSV-1 and RSV-11 for tubulin polymerization and mechanistic studies. Furthermore, RSV-1 and RSV-11 compounds inhibited the assembly of tubulin by strongly binding to the colchicine-binding site. The G2/M-phase is arrested in HepG2 cells as assessed by flow cytometry.