|Synonyms||ABT-639; ABT 639; ABT-639 free base; UNII-0G7D0CQ88I; SCHEMBL400073; 0G7D0CQ88I|
|Description||ABT-639, a new blocker of selective T-type Ca2+ channel blocker, has been found to have potential effect against neuropathic and nociceptive pain in studies. It has already been discontinued in the treatment of diabetic neuropathies.|
NNC 55-0396 dihydrochloride
NNC 55-0396 is a derivative of Mibefradil as a T-type calcium channel blocker (IC50=6.8 nM)
Mesuximide is a succinimide anticonvulsant medication. The therapeutic efficacy of methosuximide is due to its pharmacologically active metabolite, N-desmethylm...
Diltiazem is a nondihydropyridines (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia as a p...
Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.
The isotope labelled form of Nifedipine which could be used in the treatment of hypertensive and angina acting as a calcium antagonistic agent.
Imagabalin acts as a ligand for the α2δ subunit of the voltage-dependent calcium channel, which has some selectivity for the α2δ1 subunit over α2δ2. It has anxi...
Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutic...
Zonisamide sodium salt
Zonisamide is the first agent of this chemical class to be developed as an antiepileptic drug blocks repetitive firing of voltagesensitive sodium channels and r...
Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. It can lower blood pressure by reducing peripheral vascular resistance via a highly ...
(R)-(+)-Nor Verapamil Hydrochloride
This active molecular is a chiral metabolite of Verapamil which is a calcium channel blocker applicated in the treatment of hypertension, angina pectoris, cardi...
Bepridil is an amine Calcium channel antagonist that used to treat angina. But it is no longer sold in the United States. It may be a possible option in the tre...
Ca2+ Channel Agonist 1
A Ca2+ Channel Agonist that selectively acting on N-type Ca2+ channel and also be found to restrain the cdk activity at some extent. IC50: 14.23 uM (EC50, Ca2+ ...
Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
S(-)-BAY K 8644
S(-)-BAY K 8644 is an activator of voltage-sensitive L-type calcium channels with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is the...
Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Lacidipine (Lacipil, Motens) works by relaxing and opening up the blood vessels.
Manidipine 2HCl, a HCl salt form of Manidipine, is a calcium channel blocker with IC50 of 2.6 nM.
Azelnidipine is a dihydropyridine calcium channel blocker.
Diltiazem is a calcium channel antagonist. It can relax the smooth muscles in the walls of arteries, allow blood to flow more easily, and lower blood pressure. ...