|Description||ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist has been investigated as a treatment for ADHD, Alzheimer's disease, and schizophrenia.|
|Quality Standard||Enterprise standard|
Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.
Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM.
Epinastine is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is highly selective for ...
Bepotastine stimulates P-gp-mediated ATP hydrolysis with Km, Vmax, and Vmax/Km values of 1.25 mM, 108 nmol/min/mg protein, and 0.087 mL/min/mg protein, respecti...
FR-A 19 is a Histamine H2 receptor agonist with potent anti-allergic properties. It can inhibit IgE-mediated human basophil histamine release in a nanomolar ran...
Pitolisant hydrochloride is an antagonist of the histamine H3 receptor, which is used for the treatment of narcolepsy with or without cataplexy in adult patient...
This active molecular is a histamine H3 receptor antagonist. The IC50 of Enerisant is 4.9 nM in H3 receptor binding assay using (R)-α-methyl[3H]histamine. In th...
Alimemazine is a phenothiazine derivative as a Histamine Receptor antagonist. It can be used as an antipruritic . It also acts as a sedative, hypnotic, and anti...
LY-150310 is a histamine H1-receptor antagonist. It could alter prostanoid concentrations in vitro and in vivo.
Betahistine is a H1 receptor agonist, which serves as a vasodilator. It is used in Meniere disease and in vascular headaches but may exacerbate bronchial asthma...
Tripelennamine hydrochloride, the hydrochloride salt form of tripelennamine, is a blood-brain barrier penetrant and orally active H1-receptor antagonist. Tripel...
Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a ...
Famotine hydrochloride is a histamine H2 receptor antagonist. lt has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other ...
Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine. It is a racemic selective H1 receptor inverse agonist. It is used in cutane...
GS-283, an isoquinolin derivative, has been found to be histamine receptor and muscarinic receptor blocker.
GSK-239512 is a histamine H3 receptor antagonist. In Jun 2015, Phase-II for Schizophrenia in USA was discontinued. Phase II clinical trilas for the treatment of...
Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic r...
Azelastine HCl is a potent, second-generation, selective, histamine antagonist. It inhibits histamine via competing with histamine for the H1 receptor.
Ciproxifan maleate, also called as FUB-359 maleate, is a highly potent and strongly selective histamine H3 inverse agonist/antagonist (IC50 = 9.2 nM) which disp...
OUP16 is a potent and selective histamine H4 receptor(hH4R) agonist with 40-fold selectivity over the hH3R and superior to its (2S,5S)-configured optical antipo...