Abemaciclib - CAS 1231929-97-7
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Abemaciclib
Catalog Number:
1231929-97-7
Synonyms:
LY-2835219; LY 2835219
CAS Number:
1231929-97-7
Description:
Abemaciclib is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.
COA:
Inquire
MSDS:
Inquire
Targets:
CDK
Current Developer:
Eli Lilly
Chemical Structure
CAS 1231929-97-7 Abemaciclib

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Reference Reading


1.Optimising the combination dosing strategy of abemaciclib and vemurafenib in BRAF-mutated melanoma xenograft tumours.
Tate SC1, Burke TF2, Hartman D2, Kulanthaivel P2, Beckmann RP2, Cronier DM1. Br J Cancer. 2016 Mar 15;114(6):669-79. doi: 10.1038/bjc.2016.40.
BACKGROUND: Resistance to BRAF inhibition is a major cause of treatment failure for BRAF-mutated metastatic melanoma patients. Abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor, overcomes this resistance in xenograft tumours and offers a promising drug combination. The present work aims to characterise the quantitative pharmacology of the abemaciclib/vemurafenib combination using a semimechanistic pharmacokinetic/pharmacodynamic modelling approach and to identify an optimum dosing regimen for potential clinical evaluation.