ABC294640 - CAS 915385-81-8
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
ABC294640
Catalog Number:
915385-81-8
Synonyms:
ABC-294640; ABC 294640; 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide.
CAS Number:
915385-81-8
Description:
ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation.
COA:
Inquire
MSDS:
Inquire
Targets:
SPHK
Current Developer:
Apogee Biotechnology Corporation.
Chemical Structure
CAS 915385-81-8 ABC294640

Related SPHK Products


CAS 1415562-82-1 PF-543

PF-543
(CAS: 1415562-82-1)

PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, ...

CAS 915385-81-8 ABC294640

ABC294640
(CAS: 915385-81-8)

ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon adm...

CAS 1449240-68-9 K145 hydrochloride

K145 hydrochloride
(CAS: 1449240-68-9)

K145 (3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is a selective inhibitor of sphingosine kinase-2 (SphK2) and an anticancer ...

MP-A08
(CAS: 219832-49-2)

MP-A08 is a cell permeable selective inhibitor of sphingosine kinase 2 (Ki=6.9 μM) and 1 (Ki=27 μM) with little affinity for other kinases. In vitro: inhibits c...

CAS 1309444-75-4 K145

K145
(CAS: 1309444-75-4)

K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of...

CAS 1449768-36-8 SLR080811 HCl

SLR080811 HCl
(CAS: 1449768-36-8)

The hydrochloride salt form of SLR080811, an oxadiazol derivative, has been found to be a SphK inhibitor and could probably be useful in studies of some cancer,...

SLR080811
(CAS: 1449765-65-4)

SLR080811, an oxadiazol derivative, has been found to be a SphK inhibitor and could probably be useful in studies of some cancer, fibrosis, and sickle cell dise...

CAS 312636-16-1 SKI II

SKI II
(CAS: 312636-16-1)

2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) is a cell permeable, potent, and specific inhibitor of sphingosine kinase (IC50 = 0.5 μM). The compound...

VT-ME6
(CAS: 1353880-00-8)

VT-ME6 is a selective sphingosine kinase 2 inhibitor. VT-ME6 shows three-fold selectivity for SphK2 over SphK1. It has a quaternary ammonium group which is nece...

SLP120701 HCl
(CAS: 1449768-46-0)

The hydrochloride salt form of SLP120701, an oxadiazol derivative, has been found to be a Sphk inhibitor and could probably be useful in studies of some cancer,...

CAS 1415562-83-2 PF-543 Citrate

PF-543 Citrate
(CAS: 1415562-83-2)

Cell-permeant reversible inhibitor of SphK1 (IC50 value 2.0 nM; Ki value 3.6 nM). PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK...