A922500 - CAS 959122-11-3
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
A922500
Catalog Number:
959122-11-3
CAS Number:
959122-11-3
Description:
A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.
Molecular Weight:
428.48
Molecular Formula:
C26H24N2O4
COA:
Inquire
MSDS:
Inquire
Targets:
DGAT
Chemical Structure
CAS 959122-11-3 A922500

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Reference Reading


1.Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug.
Han S1, Hu L, Quach T, Simpson JS, Trevaskis NL, Porter CJ. Pharm Res. 2015 May;32(5):1830-44. doi: 10.1007/s11095-014-1579-9. Epub 2014 Dec 2.
PURPOSE: Recent studies have demonstrated the potential for a triglyceride (TG) mimetic prodrug to promote the delivery of mycophenolic acid (MPA) to the lymphatic system. Here, the metabolic pathways that facilitate the lymphatic transport of the TG prodrug (1,3-dipalmitoyl-2-mycophenoloyl glycerol, 2-MPA-TG) were examined to better inform the design of next generation prodrugs.