A-836339 - CAS 959746-77-1
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
A-836339
Catalog Number:
959746-77-1
Synonyms:
N-[3-(2-methoxyethyl)-4,5-dimethyl-1,3-thiazol-2-ylidene]-2,2,3,3-tetramethylcyclopropane-1-carboxamide;CyclopropanecarboxaMide, N-[3-(2-Methoxyethyl)-4,5-diMethyl-2(3H)-thiazolylidene]-2,2,3,3-tetraMethyl-, [N(Z)]-;1-(Tetrahydropyran-4-ylMethyl)-1H-indol-3-yl]-(2,2,3,5-tetraMethylcyclopropyl)Methanone
CAS Number:
959746-77-1
Description:
A-836339 is a synthetic and potent cannabinoid receptor full agonist. It displays a higher affinity for the peripheral CB2 receptor with Ki value of 0.64 nM over the central CB1 receptor with Ki of 270 nM in both human and rat in radioligand binding assays. It also displays analgesic, anti-inflammatory, and anti-hyperalgesic effects in mice at low doses. It exhibits a profile devoid of significant affinity at other G-protein-coupled receptors and ion channels. It has also demonstrated efficacies in the chronic constrain injury (CCI) model of neuropathic pain, skin incision, and capsaicin-induced secondary mechanical hyperalgesia models. It is intended for forensic and research applications. It was suggested to be for human consumption. It was developed by Abbott Laboratories.
Molecular Weight:
310.45
Molecular Formula:
C16H26N2O2S
Quantity:
Grams to Kilograms
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC1=C(SC(=NC(=O)C2C(C2(C)C)(C)C)N1CCOC)C
InChI:
InChI=1S/C16H26N2O2S/c1-10-11(2)21-14(18(10)8-9-20-7)17-13(19)12-15(3,4)16(12,5)6/h12H,8-9H2,1-7H3
InChIKey:
JKGIMVBQKSRTGX-UHFFFAOYSA-N
Targets:
Cannabinoid Receptor
Current Developer:
A-836339 was developed by Abbott Laboratories.
Chemical Structure
CAS 959746-77-1 A-836339

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