|Description||A-803467 is a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50=140 nM).|
PH-064 is a sodium channel inhibitor. It is extracted from patent FR 2879460 A1.
Proparacaine Hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. IC50(ED50): 3.4 mM.
CGP-47292, a triazole compound, has been found to be a metabolite of CGP-33101 that could be used agaist Lennox-Gastaut syndrome as a Sodium Channel antagonist.
Indecainide is a Sodium channel antagonists originated by Eli Lilly. Treatment for Arrhythmias and Ventricular arrhythmias was discontinued.
Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage gated sodium channels.
AZD 3161 is a Nav1.7-voltage-gated-sodium-channel-inhibitor originated by AstraZeneca. Phase-I clinical trials in Pain and Neuropathic pain was discontinued.
Mephenytoin is known to target sodium channel protein type 5 subunit alpha. It is a hydantoin-derivative anticonvulsant used to control various partial seizures...
Disopyramide phosphate is an oral antiarrhythmic agent for the treatment of cardiac arrhythmias. Disopyramide is a sodium channel blocker and therefore classifi...
Flecainide Acetate is an antiarrhythmic as a Na+ channel blocker that inhibits fast Na+ current in cardiac muscle
Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic.
Phenytoin Sodium is a potent multi-channel blocker, which blocks Na+, K+ and Ca 2+ channels and selectively blocks persistent INaP over shorter INaP actions.
(-)-Sparteine sulfate pentahydrate
(-)-Sparteine sulfate pentahydrate is an alkaloid compound which could be used as in the treatment of antiarrhythmic by blocking sodium channel.
Nav1.7-IN-2, a voltage-gated sodium channels, could be probably effective in chronic pain therapy. IC50: 80 nM.
XEN907 is a novel spirooxindole NaV1.7 blocker with IC50 of 3 nM. It shows a further 10-fold increase in potency, which represents a promising structure for fur...
Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders an...
Dibucaine HCl is a local anesthetics.Among the most potent and toxic of the long-acting local anesthetics, current use of it is generally restricted to spinal a...
The isotope labbelled form of Triamterene which is an inhibitor of ENaC and could be used as a weak diuretic.
Ranolazine is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
Mepivacaine is a tertiary amine used as a local anesthetic.
AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotecti...