|Description||A-803467 is a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50=140 nM).|
Evenamide is a selective voltage-gated sodium and/or calcium channel modulator, including subtypes Nav1.3, Nav1.7, and Nav1.8. It may be potentia useful in pre...
Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50...
Raxatrigine is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia. It acts as a selective, small-molecule, sta...
AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotecti...
Propafenone is a Class 1C antiarrhythmic as sodium channel blocker by slowing the influx of sodium ions into the cardiac muscle cells.
Riluzole is a drug used to treat amyotrophic lateral sclerosis.
Tetrodotoxin, citrate (1:1) (salt)
Tetrodotoxin, citrate (1:1) (salt), also called as TTX citrate, is the citrate salt of tetrodotoxin. Tetrodotoxin is a neurotoxin that reversibly and selectivel...
(-)-Sparteine sulfate pentahydrate
(-)-Sparteine sulfate pentahydrate is an alkaloid compound which could be used as in the treatment of antiarrhythmic by blocking sodium channel.
Nav1.7-IN-2, a voltage-gated sodium channels, could be probably effective in chronic pain therapy. IC50: 80 nM.
Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.Carbamazepine (CBZ), first marketed under the tradename Tegr...
Tetrodotoxin, frequently abbreviated as TTX, is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ...
Ethotoin is an anticonvulsant drug. It is a sodium channel inhibitor. Ethotoin can be used for the treatment of epilepsy. It is a hydantoin, similar to phenytoi...
Amiloride, a pyrazine derivative potassium-sparing diuretic, is a blocker of sodium channel in renal epithelial cells. Amiloride blocked the low threshold Ca2+ ...
Indecainide is a Sodium channel antagonists originated by Eli Lilly. Treatment for Arrhythmias and Ventricular arrhythmias was discontinued.
This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular con...
Phenytoin Sodium is a potent multi-channel blocker, which blocks Na+, K+ and Ca 2+ channels and selectively blocks persistent INaP over shorter INaP actions.
Co 102862, also known as V102862, an orally active anticonvulsant with robust activity, is a potent, broad-spectrum state-dependent inhibitor of mammalian volta...
Vinpocetine is a Phosphodiesterase inhibitor and selective for PDE1. It also blocks voltage-gated Na+ channels.
Moricizine, a Phenothiazine derivative, is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia. And ...
Dibucaine HCl is a local anesthetics.Among the most potent and toxic of the long-acting local anesthetics, current use of it is generally restricted to spinal a...