|Product Name||A 437203|
|Synonyms||2-[3-[4-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]propylsulfanyl]-1H-pyrimidin-6-one; 2-(3-(4-(2-tert-butyl-6-trifluoromethylpyrimidin-4-yl)piperazin-1-yl)propylsulfanyl)-3H-pyrimidin-4-one fumarate; A 437203; A-437203; 1160247-85-7; 220519-07-3 (anhydrous); 220519-06-2 (anhydrous free base)|
|Description||A 437203 is a selective dopamine (DA) D3 receptor antagonist suited to evaluate the physiological role(s) of D3 receptors. A 437203 shows an approximately 100-fold higher in vitro affinity for dopamine D₃ versus D₂ receptors.|
Promazine Hydrochloride is a phenothiazine used in short-term treatment of disturbed behavior and as an antiemetic.
Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist like other atypical antipsychotic agents. Ziprasidone targets dopamine neurotransmis...
Sarizotan, also known as EMD-128130, is a full 5-HT1a agonist and a dopamine D2-like agonist/partial agonist used in clinical trials for the treatment of l-dopa...
PD-118440 is a dopamine antagonist. It was identified as orally active dopamine (DA) agonists with pronounced central nervous system effects in tests including ...
PD-120697 is a novel dopamine antagonist with central dopamine agonist properties. It was identified as orally active dopamine (DA) agonists with pronounced cen...
A Serotonin-Preferring Triple Reuptake Inhibitor for the Treatment of Major Depression, with the IC50 values for serotonin, norepinephrine and dopamine reuptake...
Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals, and a dopamine D1-5 receptors agonist.
Fenoldopam is a selective D1 receptor partial agonist, binds to α2-adrenoceptors, increasing renal blood flow used as an antihypertensive agent.
Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.
Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.
Metoclopramide hydrochloride hydrate
Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist used to treat nausea and vomitin.
Pardoprunox, also called as SLV308 or DU-126891, is a D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A rec...
Bromperidol, a derivative of butyrophenone, is an antipsychotic commonly used in the treatment of schizophrenia as it could bind to the D2 dopamine and 5-HT2A s...
Pramipexole (Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
Remoxipride is a selective dopamine D2 receptor antagonist. It shows selectivity over D3 and D4 receptors with Ki values are ~ 300nM for D2 receptor, ~ 1600nM f...
Dexmethylphenidate HCl, a synthetic sympathomimetic controlled amine with CNS stimulating properties used most commonly in the treatment of attention-deficit di...
Pridopidine, also known as ACR16, is a dopamine stabilizer used in the treatment of neurologic and psychiatric disorders.
Molindone hydrochloride, an indole derivative, as an antipsychotic agent it blocks the effects of dopamine in the brain which can be used for the treatment of s...
SB269652, an allosteric modulator of D2R, consists of a tetrahydroisoquinoline pharmacophore bound in the OBS and an indole-2-carboxamide moiety bound in a SBP ...
Tiapride is a D2 and D3 dopamine receptor antagonist used to treat a variety of neurological and psychiatric disorders.