A-1155463 - CAS 1235034-55-5
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
A-1155463
Catalog Number:
1235034-55-5
Synonyms:
CHEMBL3342332; A-1155463; SCHEMBL2501550; BDBM50030754; CS-5398; HY-19725
CAS Number:
1235034-55-5
Description:
A-1155463, an effective and selective BCL-XL inhibitor, has been studied to have probable effect in restraining the growth of small cell lung cancer xenograft tumors. IC50: <0.01 nM (Ki).
Molecular Weight:
669.79
Molecular Formula:
C35H32FN5O4S2
Quantity:
Milligrams-Grams
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CN(C)CC#CC1=CC(=C(C=C1)OCCCC2=C(N=C(S2)N3CCC4=CC=CC(=C4C3)C(=O)NC5=NC6=CC=CC=C6S5)C(=O)O)F
InChI:
InChI=1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,16-19,21H2,1-2H3,(H,43,44)(H,37,39,42)
InChIKey:
SOYCFODXNRVBTI-UHFFFAOYSA-N
Targets:
Bcl-2 Family

Related Bcl-2 Family Products


CAS 803712-79-0 Obatoclax

Obatoclax
(CAS: 803712-79-0)

Obatoclax mesylate is the mesylate salt of obatoclax, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and anti...

CAS 2752-65-0 Gambogic acid

Gambogic acid
(CAS: 2752-65-0)

Gambogic acid is a natural product inhibitor of Hsp90.

Marinopyrrole A
(CAS: 1227962-62-0)

Marinopyrrole A, a new Mcl-1 inhibitor, could influence Mcl-1-Bim interaction and induce the degradation of Mcl-1 proteasomal and also lead to the apoptosis of ...

(+)-Apogossypol
(CAS: 66389-74-0)

(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins, binding and inhibiting Bcl-2 and Bcl-X(L) with high affinity and induces apoptosis of tumor cell...

Mcl1-IN-2
(CAS: 292057-76-2)

Mcl1-IN-2, a hydroxyquinoline derivative, is an Mcl-1 inhibitor.

A-1155463
(CAS: 1235034-55-5)

A-1155463, an effective and selective BCL-XL inhibitor, has been studied to have probable effect in restraining the growth of small cell lung cancer xenograft t...

CAS 65673-63-4 HA14-1

HA14-1
(CAS: 65673-63-4)

CAS 866541-93-7 AT-101 acetic acid

AT-101 acetic acid
(CAS: 866541-93-7)

AT101 acetic acid is orally bioavailable solvate of R-(-)-enantiomer of gossypol with potential antineoplastic activity. It is used as the treatment of non Hodg...

CAS 1257044-40-8 ABT-199

ABT-199
(CAS: 1257044-40-8)

Mcl1-IN-1
(CAS: 713492-66-1)

Mcl1-IN-1 is a potent Mcl-1-selective inhibitor with IC50 of 2.4 uM, relative to the related Bcl-2 family protein Bcl-xL.

CAS 303-45-7 Gossypol

Gossypol
(CAS: 303-45-7)

Gossypol is an orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cel...

CAS 923564-51-6 Navitoclax

Navitoclax
(CAS: 923564-51-6)

Spautin-1
(CAS: 1262888-28-7)

Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM.

CAS 877877-35-5 TW-37

TW-37
(CAS: 877877-35-5)

TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivat...

A-1210477
(CAS: 1668553-26-1)

A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family member...

S63845
(CAS: 1799633-27-4)

S63845, a thienopyrimidine derivative, is a potent inhibitor that specifically binds with high affinity to the BH3-binding groove of a protein of the BCL2 famil...

CAS 518303-20-3 UMI-77

UMI-77
(CAS: 518303-20-3)

UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.

Pyridoclax
(CAS: 1651890-44-6)

Pyridoclax, a pyridine derivative, has been found to be a Mcl-1 inhibitor that could induce apoptosis of cancer cells. IC50: 25 nM(Kd).

MIM1
(CAS: 509102-00-5)

MIM1 is a small molecule inhibitor of Mcl-1 (IC50= 4.8 uM) by selectively targets the BH3-binding pocket.

(S)-Gossypol acetic acid
(CAS: 1189561-66-7)

(S)-Gossypol acetic acid, a Bcl-2 inhibitor, could effectively induce the death of Jurkat cells in which Bcl-2 or Bcl-xL is overexpressed. IC50: 18.1μM and 22.9...