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What is PEG?
PEG is the common abbreviation for PEGylation–or, more properly, poly(ethylene glycol)–which refers to a chemical compound composed of repeating ethylene glycol units.
Purified PEG is most commonly available commercially as mixtures of different oligomer sizes in broadly or narrowly defined molecular weight (M.W.) ranges. For example, "PEG600" typically denotes a preparation that includes a mixture of oligomers having an average M.W. of 600. Likewise, "PEG10000" denotes a mixture of PEG molecules (n=195-265) having an average M.W. of 10,000g/mol.
Advantages of PEGylation |
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Increased bioavailability |
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Increased blood circulation of the target biomolecule / drug |
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Shielding receptor-mediated uptake by the reticuloendothelial system (RES) |
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Shielding of antigenic and immunogenic epitopes |
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Preventing recognition and degradation by proteolytic enzymes |
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Increasing the apparent size of polypeptides, thus reducing the renal filtration and altering biodistribution |
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Optimized pharmacokinetics |
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Decreased immunogenicity |
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Application of PEGylation
The protection of biological macromolecules, peptides, antibodies, proteins, and oligonucleotides is of extreme importance in biological, immunological and pharmacological applications. There is growing interest of PEG and its α- and/or ω-substituted derivates and the protection offered by the covalent attachment of PEG to target molecules. PEGylation has become the method of choice for the delivery of bio-pharmaceuticals.
Linear PEGs can offer one or two reactive groups that can bind with a functional group on the target molecule. |
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Amine PEGylation |
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[ TOP ] |
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Item Number |
Product Name |
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Y-NHS-40K |
Y-shape PEG NHS Ester, MW
40000 |
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GLUC-NHS-35K |
Glucose PEG NHS Ester, MW
35000 |
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GALA-NHS-35K |
Galactose PEG NHS Ester, MW
35000 |
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M-SCM-2000 |
Methoxy PEG Succinimidyl
Carboxymethyl Ester, MW 2000 |
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M-SCM-5000 |
Methoxy PEG Succinimidyl
Carboxymethyl Ester, MW 5000 |
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77M-SCM-20K |
Methoxy PEG Succinimidyl
Carboxymethyl Ester, MW 20000 |
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M-SCM-30K |
Methoxy PEG Succinimidyl
Carboxymethyl Ester, MW 30000 |
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M-SCM-35K |
Methoxy PEG Succinimidyl
Carboxymethyl Ester, MW 35000 |
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M-SCM-40K |
Methoxy PEG Succinimidyl
Carboxymethyl Ester, MW 40000 |
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Thiol PEGylation |
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[ TOP ] |
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Item Number |
Product Name |
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Y-MAL-40K |
Y-shape PEG Maleimide, MW
40000 |
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M-MAL-2000 |
Methoxy PEG Maleimide, MW 2000 |
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M-MAL-5000 |
Methoxy PEG Maleimide, MW 5000 |
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M-MAL-20K |
Methoxy PEG Maleimide, MW
20000 |
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M-MAL-30K |
Methoxy PEG Maleimide, MW
30000 |
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M-MAL-40K |
Methoxy PEG Maleimide, MW
40000 |
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M-VS-5000 |
Methoxy PEG Vinylsulfone, MW
5000 |
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M-VS-20K |
Methoxy PEG Vinylsulfone, MW
20000 |
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M-SH-5000 |
Methoxy PEG Thiol, MW 5000 |
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M-SH-20K |
Methoxy PEG Thiol, MW 20000 |
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N-Terminal PEGylation |
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[ TOP ] |
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Item Number |
Product Name |
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Y-ALD-40K |
Y-shape PEG Aldehyde, MW
40000 |
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M-ALD-5000
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Methoxy PEG Propionaldehyde,
MW 5000 |
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M-ALD-20K |
Methoxy PEG Propionaldehyde,
MW 20000 |
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M-ALD-30K |
Methoxy PEG Propionaldehyde,
MW 30000 |
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M-ALD-40K |
Methoxy PEG Propionaldehyde,
MW 40000 |
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Other Linear Methoxy PEG Derivatives |
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[ TOP ] |
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Item Number |
Product Name |
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M-NH2-2000 |
Methoxy PEG Amine, HCl Salt,
MW 2000 |
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M-NH2-5000 |
Methoxy PEG Amine, HCl Salt,
MW 5000 |
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M-NH2-20K |
Methoxy PEG Amine, HCl Salt,
MW 20000 |
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M-NH2-30K |
Methoxy PEG Amine, HCl Salt,
MW 30000 |
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M-NH2-40K |
Methoxy PEG Amine, HCl Salt,
MW 40000 |
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M-HZ-5000 |
Methoxy PEG Hydrazide, MW 5000 |
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M-HZ-20K |
Methoxy PEG Hydrazide, MW
20000 |
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Homobifunctional PEG Derivatives |
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[ TOP ] |
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Item Number
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Product Name |
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COOH-PEG2000-COOH
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Carboxyl PEG Carboxyl, MW
2000 |
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COOH-PEG3500-COOH
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Carboxyl PEG Carboxyl, MW
3500 |
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COOH-PEG5000-COOH
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Carboxyl PEG Carboxyl, MW
5000 |
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COOH-PEG7500-COOH
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Carboxyl PEG Carboxyl, MW 7500
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NH2-PEG2000-NH2
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Amine PEG Amine, HCl Salt, MW
2000 |
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NH2-PEG3500-NH2
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Amine PEG Amine, HCl Salt, MW
3500 |
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NH2-PEG5000-NH2
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Amine PEG Amine, HCl Salt, MW
5000 |
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NH2-PEG7500-NH2
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Amine PEG Amine, HCl Salt, MW
7500 |
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MAL-PEG2000-MAL
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Maleimide PEG Maleimide, MW
2000 |
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MAL-PEG3500-MAL
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Maleimide PEG Maleimide, MW
3500 |
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MAL-PEG5000-MAL
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Maleimide PEG Maleimide, MW
5000 |
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MAL-PEG7500-MAL
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Maleimide PEG Maleimide, MW
7500 |
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Heterobifunctional PEG Derivatives |
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[ TOP ] |
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Item Number
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Product Name |
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HO-PEG2000-COOH
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Hydroxyl PEG Carboxyl, MW
2000 |
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HO-PEG3500-COOH
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Hydroxyl PEG Carboxyl, MW
3500 |
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HO-PEG5000-COOH
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Hydroxyl PEG Carboxyl, MW
5000 |
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HO-PEG7500-COOH
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Hydroxyl PEG Carboxyl, MW
7500 |
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HO-PEG2000-NH2
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Hydroxyl PEG Amine, HCl Salt,
MW 2000 |
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HO-PEG3500-NH2
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Hydroxyl PEG Amine, HCl Salt,
MW 3500 |
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HO-PEG5000-NH2
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Hydroxyl PEG Amine, HCl Salt,
MW 5000 |
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HO-PEG7500-NH2
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Hydroxyl PEG Amine, HCl Salt,
MW 7500 |
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TBOC-PEG2000-NH2
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t-Boc Amine PEG Amine, HCl
Salt, MW 2000 |
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TBOC-PEG3500-NH2
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t-Boc Amine PEG Amine, HCl
Salt, MW 3500 |
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TBOC-PEG5000-NH2
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t-Boc Amine PEG Amine, HCl
Salt, MW 5000 |
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TBOC-PEG7500-NH2
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t-Boc Amine PEG Amine, HCl
Salt, MW 7500 |
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NH2-PEG2000-COOH
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Amine PEG Carboxyl, HCl Salt,
MW 2000 |
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NH2-PEG3500-COOH
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Amine PEG Carboxyl, HCl Salt,
MW 3500 |
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NH2-PEG5000-COOH
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Amine PEG Carboxyl, HCl Salt,
MW 5000 |
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NH2-PEG7500-COOH
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Amine PEG Carboxyl, HCl Salt,
MW 7500 |
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TBOC-PEG2000-NHS
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t-Boc Amine PEG NHS Ester, MW
2000 |
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TBOC-PEG3500-NHS
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t-Boc Amine PEG NHS Ester, MW
3500 |
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TBOC-PEG5000-NHS
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t-Boc Amine PEG NHS Ester, MW
5000 |
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TBOC-PEG7500-NHS
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t-Boc Amine PEG NHS Ester, MW
7500 |
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FMOC-PEG2000-NHS
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Fmoc Amine PEG NHS Ester, MW
2000 |
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FMOC-PEG3500-NHS
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Fmoc Amine PEG NHS Ester, MW
3500 |
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FMOC-PEG5000-NHS
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Fmoc Amine PEG NHS Ester, MW
5000 |
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FMOC-PEG7500-NHS
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Fmoc Amine PEG NHS Ester, MW
7500 |
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HS-PEG3500-COOH
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Thiol PEG Carboxyl, MW 3500 |
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HS-PEG5000-COOH
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Thiol PEG Carboxyl, MW 5000
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ACLT-PEG2000-NHS
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Acrylate PEG NHS Ester, MW
2000 |
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ACLT-PEG3500-NHS
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Acrylate PEG NHS Ester, MW
3500 |
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ACLT-PEG5000-NHS
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Acrylate PEG NHS Ester, MW
5000 |
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ACLT-PEG7500-NHS
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Acrylate PEG NHS Ester, MW
7500 |
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MAL-PEG2000-NH2
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Maleimide PEG Amine, TFA Salt,
MW2000 |
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MAL-PEG3500-NH2
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Maleimide PEG Amine, TFA Salt,
MW 3500 |
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MAL-PEG5000-NH2
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Maleimide PEG Amine, TFA Salt,
MW 5000 |
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MAL-PEG7500-NH2 |
Maleimide PEG Amine, TFA Salt,
MW 7500 |
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MAL-PEG2000-NHS
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Maleimide PEG NHS Ester, MW
2000 |
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MAL-PEG3500-NHS
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Maleimide PEG NHS Ester, MW
3500 |
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MAL-PEG5000-NHS
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Maleimide PEG NHS Ester, MW
5000 |
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MAL-PEG7500-NHS
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Maleimide PEG NHS Ester, MW
7500 |
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MAL-PEG2000-COOH
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Maleimide PEG Carboxyl, MW
2000 |
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MAL-PEG3500-COOH
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Maleimide PEG Carboxyl, MW
3500 |
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MAL-PEG5000-COOH
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Maleimide PEG Carboxyl, MW
5000 |
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MAL-PEG7500-COOH
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Maleimide PEG Carboxyl, MW
7500 |
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BIOTIN-PEG2000-NHS
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Biotin PEG NHS Ester, MW 2000 |
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BIOTIN-PEG3500-NHS
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Biotin PEG NHS Ester, MW 3500 |
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BIOTIN-PEG5000-NHS
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Biotin PEG NHS Ester, MW 5000 |
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BIOTIN-PEG7500-NHS
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Biotin PEG NHS Ester, MW 7500
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BIOTIN-PEG2000-MAL
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Biotin PEG Maleimide, MW 2000 |
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BIOTIN-PEG3500-MAL
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Biotin PEG Maleimide, MW 3500 |
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BIOTIN-PEG5000-MAL
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Biotin PEG Maleimide, MW 5000 |
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BIOTIN-PEG7500-MAL
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Biotin PEG Maleimide, MW 7500 |
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OPSS-PEG3500-NHS
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OPSS PEG NHS Ester, MW 3500 |
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OPSS-PEG5000-NHS
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OPSS PEG NHS Ester, MW 5000 |
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Multi-arm PEG Derivatives |
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[ TOP ] |
| 4ARM-PEG Derivatives (pentaerythritol core) |
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Item Number |
Product Name |
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4ARM-NH2-5000 |
4arm PEG Amine, HCl Salt, MW 5000
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4ARM-NH2-10K |
4arm PEG Amine, HCl Salt, MW 10000
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4ARM-NH2-20K |
4arm PEG Amine, HCl Salt, MW 20000
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4ARM-COOH-10K |
4arm PEG Carboxyl, MW 10000 |
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4ARM-COOH-20K |
4arm PEG Carboxyl, MW 20000 |
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4ARM-MAL-10K |
4arm PEG Maleimide, MW 10000 |
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4ARM-MAL-20K |
4arm PEG Maleimide, MW 20000 |
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4ARM-SS-10K |
4arm PEG Succinimidyl Succinate, MW 10000
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4ARM-SS-20K |
4arm PEG Succinimidyl Succinate, MW 20000
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4ARM-SG-10K |
4arm PEG Succinimidyl Glutarate, MW 10000
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4ARM-SG-20K |
4arm PEG Succinimidyl Glutarate, MW 20000
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8ARM-PEG Derivatives (hexaglycerin core) |
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Item Number |
Product Name |
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8ARM-NH2-10K
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8arm PEG Amine, HCl
Salt, MW 10000 |
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8ARM-NH2-20K
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8arm PEG Amine, HCl
Salt, MW 20000 |
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8ARM-NH2-40K
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8arm PEG Amine, HCl
Salt, MW 40000 |
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8ARM-COOH-10K
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8arm PEG Carboxyl, MW
10000 |
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8ARM-COOH-20K
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8arm PEG Carboxyl, MW
20000 |
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8ARM-COOH-40K
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8arm PEG Carboxyl, MW
40000 |
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8ARM-SS-10K
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8arm PEG Succinimidyl
Succinate, MW 10000 |
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8ARM-SS-20K
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8arm PEG Succinimidyl
Succinate, MW 0000 |
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8ARM-SS-40K
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8arm PEG Succinimidyl
Succinate, MW 40000 |
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8ARM-SG-10K
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8arm PEG Succinimidyl
Glutarate, MW 10000 |
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8ARM-SG-15K
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8arm PEG Succinimidyl
Glutarate, MW 15000 |
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8ARM-SG-20K
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8arm PEG Succinimidyl
Glutarate, MW 20000 |
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8ARM-SG-40K
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8arm PEG Succinimidyl
Glutarate, MW 40000 |
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8ARM-PEG Derivatives (tripentaerythritol core) |
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Item Number |
Product Name |
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8ARM(TP)-NH2-10K
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8arm PEG Amine, HCl
Salt, MW 10000 |
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8ARM(TP)-NH2-20K
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8arm PEG Amine, HCl
Salt, MW 20000 |
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8ARM(TP)-NH2-40K
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8arm PEG Amine, HCl
Salt, MW 40000 |
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8ARM(TP)-COOH-10K
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8arm PEG Carboxyl, MW
10000 |
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8ARM(TP)-COOH-20K
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8arm PEG Carboxyl, MW
20000 |
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8ARM(TP)-COOH-40K
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8arm PEG Carboxyl, MW
40000 |
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8ARM(TP)-SS-10K
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8arm PEG Succinimidyl
Succinate, MW 10000 |
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8ARM(TP)-SS-20K
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8arm PEG Succinimidyl
Succinate, MW 20000 |
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8ARM(TP)-SS-40K
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8arm PEG Succinimidyl
Succinate, MW 40000 |
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8ARM(TP)-SG-10K
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8arm PEG Succinimidyl
Glutarate, MW 10000 |
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8ARM(TP)-SG-15K
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8arm PEG Succinimidyl
Glutarate, MW 15000 |
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8ARM(TP)-SG-20K
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8arm PEG Succinimidyl
Glutarate, MW 20000 |
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8ARM(TP)-SG-40K
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8arm PEG Succinimidyl
Glutarate, MW 40000 |
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Linear Methoxy PEG Raw Materials |
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[ TOP ] |
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Item Number |
Product Name |
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M-PEG-5000
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Methoxy Polyethylene
Glylcol, MW 5000 |
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M-PEG-10K
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Methoxy Polyethylene
Glylcol, MW 10000 |
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M-PEG-20K
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Methoxy Polyethylene
Glylcol, MW 20000 |
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M-PEG-30K
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Methoxy Polyethylene
Glylcol, MW 30000 |
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M-PEG-40K
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Methoxy Polyethylene
Glylcol, MW 40000 |
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Multi Arm PEG Raw Materials |
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[ TOP ] |
| 4ARM-PEG Raw Materials (pentaerythritol core) |
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Item Number |
Product Name |
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4ARM-PEG-2000
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4arm Polyethylene
Glycol, MW 2000 |
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4ARM-PEG-5000
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4arm Polyethylene
Glycol, MW 5000 |
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4ARM-PEG-10K
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4arm Polyethylene
Glycol, MW 10000 |
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4ARM-PEG-15K
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4arm Polyethylene
Glycol, MW 15000 |
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4ARM-PEG-20K
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4arm Polyethylene
Glycol, MW 20000 |
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8ARM-PEG Raw Materials (hexaglycerin core) |
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Item Number |
Product Name |
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8ARM-PEG-10K
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8arm Polyethylene
Glycol, MW 10000 |
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8ARM-PEG-15K
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8arm Polyethylene
Glycol, MW 15000 |
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8ARM-PEG-20K
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8arm Polyethylene
Glycol, MW 20000 |
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8ARM-PEG-40K
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8arm Polyethylene
Glycol, MW 40000 |
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8ARM-PEG Raw Materials (tripentaerythritol core) |
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Item Number |
Product Name |
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8ARM(TP)-PEG-10K
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8arm Polyethylene
Glycol, MW 10000 |
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8ARM(TP)-PEG-15K
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8arm Polyethylene
Glycol, MW 15000 |
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8ARM(TP)-PEG-20K
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8arm Polyethylene
Glycol, MW 20000 |
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8ARM(TP)-PEG-40K
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8arm Polyethylene
Glycol, MW 40000 |
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