8-Fluoro-quinazoline-2,4-diamine - CAS 119584-79-1

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CAS 119584-79-1 8-Fluoro-quinazoline-2,4-diamine
Reference Reading
1.Metabolomic analysis of riboswitch containing E. coli recombinant expression system.
Muhamadali H1, Xu Y1, Morra R2, Trivedi DK1, Rattray NJ1, Dixon N2, Goodacre R1. Mol Biosyst. 2016 Jan 26;12(2):350-61. doi: 10.1039/c5mb00624d.
In this study we have employed metabolomics approaches to understand the metabolic effects of producing enhanced green fluorescent protein (eGFP) as a recombinant protein in Escherichia coli cells. This metabolic burden analysis was performed against a number of recombinant expression systems and control strains and included: (i) standard transcriptional recombinant expression control system BL21(DE3) with the expression plasmid pET-eGFP, (ii) the recently developed dual transcriptional-translational recombinant expression control strain BL21(IL3), with pET-eGFP, (iii) BL21(DE3) with an empty expression plasmid pET, (iv) BL21(IL3) with an empty expression plasmid, and (v) BL21(DE3) without an expression plasmid; all strains were cultured under various induction conditions. The growth profiles of all strains together with the results gathered by the analysis of the Fourier transform infrared (FT-IR) spectroscopy data, identified IPTG-dependent induction as the dominant factor hampering cellular growth and metabolism, which was in general agreement with the findings of GC-MS analysis of cell extracts and media samples.
2.Biogenic Nanoparticles from Schwanniomyces occidentalis NCIM 3459: Mechanistic Aspects and Catalytic Applications.
Mohite P1, Apte M1, Kumar AR1, Zinjarde S2. Appl Biochem Biotechnol. 2016 Feb 22. [Epub ahead of print]
When cells of Schwanniomyces occidentalis NCIM 3459 were incubated with 1 mM tetrachloroauric acid (HAuCl4) or silver nitrate (AgNO3), cell-associated nanoparticles were obtained. Their presence was confirmed by scanning electron microscope observations. The cell-free supernatant (CFS) of the yeast mediated the synthesis of gold nanoparticles. On account of the difficulties associated with the use of cell-bound nanoparticles, further work was restricted to extracellular nanoparticles. It was hypothesized that the CFS contained thermostable biomolecule(s) that mediated metal reduction reactions. Extraction of the CFS with chloroform/methanol (2:1) and subsequent separation by preparative thin layer chromatography led to the activity-guided purification of a glycolipid. The glycolipid was hydrolyzed and the glycone (glucose) and aglycone components (palmitic acid and oleic acid) were identified by gas chromatography-mass spectrometry. The purified glycolipid mediated the synthesis of gold and silver nanoparticles that were characterized by using an X-ray diffractometer and transmission electron microscope (TEM).
3.Siloxymethylamines as Aminomethylation Reagents for Amines Leading to Labile Diaminomethanes That can be Trapped as Their [Mo(CO)4 ] Complexes.
Sharma HK1, Gonzalez PE1, Craig AL1, Chakrabarty S1, Metta-Magaña A1, Pannell KH2. Chemistry. 2016 Apr 25. doi: 10.1002/chem.201600810. [Epub ahead of print]
Compound Et3 SiOCH2 NMe2 transfers Me2 NCH2 to R2 NH (R2 =Et2 , PhMe, [Cr(η6 -C6 H5 )(CO)3 ]Me, PhH) to form previously unknown diaminomethanes, Me2 NCH2 NR2 and, in the case of R2 =PhH, the triamine Me2 NCH2 N(Ph)CH2 NMe2 . The diaminomethanes exhibit an unreported disproportionation to a mixture of (R2 N)2 CH2 , (Me2 N)2 CH2 , and Me2 NCH2 NR2 , which can be trapped as their [Mo(CO)4 (diamine)] complexes. Whereas PhMeNCH2 NMe2 is a labile material, the metal-substituted ([(η6 -C6 H5 )Cr(CO)3 ]MeNCH2 NMe2 is a stable material. The triamine Me2 NCH2 N(Ph)CH2 NMe2 is unstable with respect to transformation to 1,3,5-triphenyltriazine, but is readily trapped as the bidentate-triamineMo(CO)4 . All metal complexes were characterized by single-crystal X-ray diffraction.
4.Oxidative Dimerization of Triarylamines Promoted by WCl6, Including the Solid State Isolation and the Crystallographic Characterization of a Triphenylammonium Salt.
Bortoluzzi M1, Marchetti F2, Pampaloni G2, Pinzino C3, Zacchini S4. Inorg Chem. 2016 Jan 19;55(2):887-93. doi: 10.1021/acs.inorgchem.5b02392. Epub 2015 Dec 23.
The triphenylammonium salt [NHPh3][WCl6], 1, and the product of the C-C dimerization of triphenylamine, Ph2N(C6H4)2NPh2, 2, were afforded from the reaction between WCl6 and NPh3 in CH2Cl2. Compound 2 was isolated in 43% yield upon hydrolysis of the reaction mixture. The X-ray structure of 1 provides the first crystallographic characterization of the triphenylammonium ion. Combined EPR and DFT studies gave insight into the reaction mechanism, and allowed the identification of WCl5···[Cl(C6H4)NPh2] as a presumable key intermediate. The reactions of WCl6 with 4-bromotriphenylamine, 4,4'-dimethyltriphenylamine, 9-phenylcarbazole, followed by hydrolytic treatment, led to the dimerization products 3-6, in admixture with variable amounts of the parent amines. N,N,N',N'-tetrakis(4-bromophenyl)-[1,1'-biphenyl]-4,4'-diamine, 3, was isolated in 60% yield from the reaction of WCl6 with 4,4'-dibromotriphenylamine.
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