8-Aza-7-deaza-2'-deoxyguanosine - CAS 100644-70-0
Category:
Nucleosides
Product Name:
8-Aza-7-deaza-2'-deoxyguanosine
Catalog Number:
100644-70-0
CAS Number:
100644-70-0
Molecular Weight:
267.24
Molecular Formula:
C10H13N5O4
COA:
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MSDS:
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Structure\Application:
2'-Deoxy-Nucleosides
Chemical Structure
CAS 100644-70-0 8-Aza-7-deaza-2'-deoxyguanosine

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Reference Reading


1.Alternating d(G-C)3 and d(C-G)3 hexanucleotides containing 7-deaza-2'-deoxyguanosine or 8-aza-7-deaza-2'-deoxyguanosine in place of dG.
Seela F1, Driller H. Nucleic Acids Res. 1989 Feb 11;17(3):901-10.
The synthesis of alternating hexamers (8-13) derived from d(C-G)3 or d(G-C)3 but containing c7z8Gd (2) or c7Gd (3) instead of dG is described employing phosphoramidite-chemistry. Apart from the isobutyryl group the dimethylaminomethylene residue was used for the nucleobase-protection of 3. The methyl- and the cyanoethyl-phosphoramidites of 3 (5a-c) were synthesized. They were employed together with those of c7G or c7z8Gd in automated oligonucleotide synthesis. Tm-values as well as thermodynamic data of the oligomers 9, 10, 12, and 13 indicated that duplexes were destabilized if c7Gd replaced dG, whereas c7z8Gd stabilized the duplex structure. In contrast to d(C-G)3 which underwent salt-dependent B-Z transition, CD-spectra of oligomers containing c7Gd or c7z8Gd in place of dG showed retained B-conformation.