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7-TRIFLUOROMETHYL-2,3,4,5-TETRAHYDRO-1H-BENZO[B]AZEPINE HYDROCHLORIDE - CAS 220107-24-4

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Category
Main Product
Product Name
7-TRIFLUOROMETHYL-2,3,4,5-TETRAHYDRO-1H-BENZO[B]AZEPINE HYDROCHLORIDE
Catalog Number
220107-24-4
Synonyms
7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepine; hydrochloride; 7-Trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepinehydrochloride; 220107-24-4; CTK8E0755; HE325937
CAS Number
220107-24-4
Molecular Weight
251.6758296
Molecular Formula
C11H13ClF3N
COA
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MSDS
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Canonical SMILES
C1CCNC2=C(C1)C=C(C=C2)C(F)(F)F.Cl
InChI
InChI=1S/C11H12F3N.ClH/c12-11(13,14)9-4-5-10-8(7-9)3-1-2-6-15-10;/h4-5,7,15H,1-3,6H2;1H
InChIKey
VNTSTTRWBJBAMN-UHFFFAOYSA-N
Structure
CAS 220107-24-4 7-TRIFLUOROMETHYL-2,3,4,5-TETRAHYDRO-1H-BENZO[B]AZEPINE HYDROCHLORIDE
Specification
Purity
95%
Reference Reading
1.A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain.
McGowan E1, Hoyt SB, Li X, Lyons KA, Abbadie C. Anesth Analg. 2009 Sep;109(3):951-8. doi: 10.1213/ane.0b013e3181b01b02.
BACKGROUND: Voltage-gated sodium channels (Na(v)1) are expressed in primary sensory neurons where they influence excitability via their role in the generation and propagation of action potentials. Recently, human genetic data have shown that one sodium channel subtype, Na(v)1.7, plays a major role in pain. We performed these studies to characterize the antinociceptive effects of N-[(R)-1-((R)-7-chloro-1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-2-(2-fluorophenyl)-ethyl]-4-fluoro-2-trifluoromethyl-benzamide (BZP), a non-central nervous system (CNS) penetrant small molecule with high affinity and preferential selectivity for Na(v)1.7 over Na(v)1.8 and Na(v)1.5.
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