|Product Name||6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-5,11-dimethyl-|
|Synonyms||CHEMBL1673039; SCHEMBL618262; BDBM50337127; ZINC66066276; CS-4938; HY-14403|
|Description||An effective inhibitior of ERK5, could probably be used as an antitumor agent. IC50: 0.19μM(EC50 for cellular),of 0.087 μM(for enzymatic) and 0.087 μM(for LRRK2).|
Potent and selective ERK5 inhibitor; inhibits EGFR-induced ERK5 autophosphorylation (EC50 = 90 nM) and ERK5 enzymatic activity (IC50 = 162 nM). Exhibits at leas...
FR180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.FR1802...
Sodium Tauroursodeoxycholate (TUDC)
Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.
GDC-0994, also known as RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon or...
XMD8-92, via inhibition of BMK1 activation, significantly induces p21 expression in cells, and mediates suppression of cancer cell proliferation.
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability an...
Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and a useful and prospective compound in the prevention and treatment for vas...
TIC10, also known as ONC201, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses ...
An effective inhibitior of ERK5, could probably be used as an antitumor agent. IC50: 0.19μM(EC50 for cellular),of 0.087 μM(for enzymatic) and 0.087 μM(for LRRK2...
VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK, which is extracellular signal-regulated kinases. It is an antitumor agent and potently ...
Ulixertinib, also known as VRT752271, is an inhibitors of ERK protein kinase.
SCH772984 is an potent and selective ERK inhibitor with potential anticancer activity. SCH722984 showed activity against BRAF mutant, NRAS mutant and wild-type ...
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM.