6-O-α-D-Maltosyl-β-cyclodextrin - CAS 104723-60-6
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
6-O-α-D-Maltosyl-β-cyclodextrin
Catalog Number:
104723-60-6
CAS Number:
104723-60-6
Description:
6-O-α-D-Maltosyl-β-cyclodextrin is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol and is much less cytotoxic to human erythrocytes and Caco-2 cells.
Molecular Weight:
1459.27
Molecular Formula:
C54H90O45
COA:
Inquire
MSDS:
Inquire
Targets:
Others
Chemical Structure
CAS 104723-60-6 6-O-α-D-Maltosyl-β-cyclodextrin

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Reference Reading


1.Complex of branched cyclodextrin and lidocaine prolonged the duration of peripheral nerve block.
Suzuki R1, Arai YC, Hamayasu K, Fujita K, Hara K, Yamaguchi T, Sasaguri S. J Anesth. 2009;23(2):295-7. doi: 10.1007/s00540-008-0720-5. Epub 2009 May 15.
Although laboratories have tried to synthesize new local anesthetics, currently available local anesthetics rarely provide prolonged regional blockade. New models of sustained-release preparations of local anesthetics with liposomes and microspheres have been studied to prolong the duration of the effects of the local anesthetics. In the present study, we examined whether a complex of a branched cyclodextrin (CD), 6-O-alpha-D-maltosyl-beta-cyclodextrin (G2-beta-CD) and lidocaine could prolong local nerve block when compared with plain lidocaine. The sciatic nerve in male Sprague-Dawley rats was blocked with plain lidocaine (n = 10), the complex of G2-beta-CD + lidocaine (n = 10), or plain G2-beta-CD (n = 4). Sensory block was assessed with a hotplate set at 56 degrees C. The median duration of the block was longer in the complex group than in the plain lidocaine group (110 min; range, 70-150 min vs 55 min; range, 40-80 min; P < 0.05), thus demonstrating that the complex with CyD significantly prolonged the nerve block effect of lidocaine.
2.Experimental and Theoretical Investigations on the Supermolecular Structure of Isoliquiritigenin and 6-O-α-D-Maltosyl-β-cyclodextrin Inclusion Complex.
Li B1, Liu B2, Li J3, Xiao H4, Wang J5, Liang G6. Int J Mol Sci. 2015 Aug 4;16(8):17999-8017. doi: 10.3390/ijms160817999.
Isoliquiritigenin (ILTG) possesses many pharmacological properties. However, its poor solubility and stability in water hinders its wide applications. The solubility of bioactive compounds can often be enhanced through preparation and delivery of various cyclodextrin (CD) inclusion complexes. The 6-O-α-D-maltosyl-β-CD (G2-β-CD), as one of the newest developments of CDs, has high aqueous solubility and low toxicity, especially stable inclusion characteristics with bioactive compounds. In this work, we for the first time construct and characterize the supermolecular structure of ILTG/G2-β-CD by scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffractometry (XRD). The solubility of ILTG in water at 25 °C rises from 0.003 to 0.717 mg/mL by the encapsulation with G2-β-CD. Our experimental observations on the presence of the ILTG/G2-β-CD inclusion complex are further supported by the ONIOM(our Own N-layer Integrated Orbital molecular Mechanics)-based QM/MM (Quantum Mechanics/Molecular Mechanics) calculations, typically substantiating these supermolecular characteristics, such as detailed structural assignments, preferred binding orientations, selectivity, solvent effects, interaction energies and forces of the ILTG/G2-β-CD inclusion complex.